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Metabolic Messengers: bile acids.

作者信息

Perino Alessia, Schoonjans Kristina

机构信息

Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

出版信息

Nat Metab. 2022 Apr;4(4):416-423. doi: 10.1038/s42255-022-00559-z. Epub 2022 Mar 25.

DOI:10.1038/s42255-022-00559-z
PMID:35338368
Abstract
摘要

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Metabolic Messengers: bile acids.代谢信使：胆汁酸。
Nat Metab. 2022 Apr;4(4):416-423. doi: 10.1038/s42255-022-00559-z. Epub 2022 Mar 25.
2
Signal transduction and hepatocellular bile acid transport: cross talk between bile acids and second messengers.信号转导与肝细胞胆汁酸转运：胆汁酸与第二信使之间的相互作用
Gastroenterology. 1999 Aug;117(2):433-52. doi: 10.1053/gast.1999.0029900433.
3
[The metabolic product of dehydrocholic acid in dogs].[狗体内脱氢胆酸的代谢产物]
Hoppe Seylers Z Physiol Chem. 1953;295:67-70. doi: 10.1515/bchm2.1953.295.1.67.
4
On the conjugation and formation of bile acids in the human liver.关于人体肝脏中胆汁酸的结合与形成
Acta Chir Scand Suppl. 1958;115(Suppl 233):1-19.
5
On the conjugation and formation of bile acids in the human liver. V. On the conjugation of cholic acid - 2414C in homogenates of human liver specimens stored in deep-freeze unit; bile acids and steroids 65.关于人肝脏中胆汁酸的结合与形成。五、关于人肝脏标本在深冻装置中储存后的匀浆中胆酸 - 2414C 的结合；胆汁酸与类固醇65。
Acta Chir Scand. 1958;115(3):203-7.
6
[Conjugation of bile acids by the perfused rat liver].[灌注大鼠肝脏中胆汁酸的结合作用]
C R Hebd Seances Acad Sci. 1961 Feb 20;252:1206-8.
7
On the conjugation and formation of bile acids in the human liver. VI. On the conjugation of cholic acid -2414C in human liver homogenates in various diseases with special reference to patients with jaundice; bile acids and steroids 66.关于人肝脏中胆汁酸的结合与形成。VI. 关于不同疾病状态下人肝脏匀浆中胆酸-24¹⁴C的结合情况，特别提及黄疸患者；胆汁酸与类固醇66
Acta Chir Scand. 1958;115(3):208-26.
8
STERO-BILE ACIDS AND BILE STEROLS. LIII. SYNTHESIS AND METABOLISM OF CHOLIC ALDEHYDE.甾体胆汁酸与胆汁甾醇。LIII. 胆醛的合成与代谢
J Biochem. 1963 Jul;54:47-50. doi: 10.1093/oxfordjournals.jbchem.a127745.
9
The formation of cholic acid from 3alpha, 7alpha-dihydroxycoprostane in the rat.大鼠体内由3α, 7α-二羟基胆烷生成胆酸的过程。
Biochim Biophys Acta. 1956 Mar;19(3):556-7. doi: 10.1016/0006-3002(56)90485-1.
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Stero-bile acids and bile sterols. XLV. The metabolism of 3alpha,7alpha,12alpha-trihydroxy-coprostane in toad liver homogenate.甾体胆汁酸和胆汁甾醇。XLV。蟾蜍肝匀浆中3α,7α,12α-三羟基粪甾烷的代谢
J Chir (Paris). 1962 Jul;84:1-4.

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Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System.大脑中法尼酯X受体的激活通过交感神经系统改变棕色脂肪组织功能。
Front Mol Neurosci. 2022 Jan 4;14:808603. doi: 10.3389/fnmol.2021.808603. eCollection 2021.
2
Characterization of gut microbial structural variations as determinants of human bile acid metabolism.肠道微生物结构变化特征可作为人类胆汁酸代谢的决定因素。
Cell Host Microbe. 2021 Dec 8;29(12):1802-1814.e5. doi: 10.1016/j.chom.2021.11.003. Epub 2021 Nov 29.
3
Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice.
2型糖尿病合并周围神经病变患者肠道微生物群、粪便和血清代谢物的综合分析
J Endocrinol Invest. 2025 Jul 8. doi: 10.1007/s40618-025-02640-2.
4
Tributyltin Alters Seric Bile Acid Pool Composition in Male Rats.三丁基锡改变雄性大鼠血清胆汁酸池组成。
Toxics. 2025 May 26;13(6):440. doi: 10.3390/toxics13060440.
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Metabolic acclimation to warming links unexpected immune activation and sexual dimorphism attenuation in Xenopus tropicalis.热带爪蟾对变暖的代谢适应将意外的免疫激活与性二态性减弱联系起来。
Commun Biol. 2025 Jun 23;8(1):952. doi: 10.1038/s42003-025-08340-0.
6
Bile acid accumulation induced by miR-122 deficiency in liver parenchyma promotes cancer cell growth in hepatocellular carcinoma.肝实质中miR-122缺乏诱导的胆汁酸积累促进肝细胞癌中癌细胞的生长。
Mol Ther Nucleic Acids. 2025 May 14;36(2):102560. doi: 10.1016/j.omtn.2025.102560. eCollection 2025 Jun 10.
7
The potential mechanisms of reciprocal regulation of gut microbiota-liver immune signaling in metabolic dysfunction-associated steatohepatitis revealed in multi-omics analysis.多组学分析揭示代谢功能障碍相关脂肪性肝炎中肠道微生物群与肝脏免疫信号相互调节的潜在机制。
mSystems. 2025 Jul 22;10(7):e0051825. doi: 10.1128/msystems.00518-25. Epub 2025 Jun 10.
8
Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway.来自变色紫菜的紫菜多糖通过微生物群-胆汁酸-神经酰胺途径预防代谢综合征。
iScience. 2025 May 7;28(6):112603. doi: 10.1016/j.isci.2025.112603. eCollection 2025 Jun 20.
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Metabolic disorders in polycystic ovary syndrome: from gut microbiota biodiversity to clinical intervention.多囊卵巢综合征中的代谢紊乱：从肠道微生物群生物多样性到临床干预
Front Endocrinol (Lausanne). 2025 Apr 28;16:1526468. doi: 10.3389/fendo.2025.1526468. eCollection 2025.
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Association of Age-Related Macular Degeneration with Cholelithiasis.年龄相关性黄斑变性与胆石症的关联
Ophthalmol Sci. 2025 Mar 19;5(4):100771. doi: 10.1016/j.xops.2025.100771. eCollection 2025 Jul-Aug.
肠源成纤维细胞生长因子 15 可防止小鼠垂直袖状胃切除术的有害影响。
Nat Commun. 2021 Aug 6;12(1):4768. doi: 10.1038/s41467-021-24914-y.
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Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.肠道缺氧诱导因子 2α 调节乳酸水平以塑造肠道微生物组并改变产热。
Cell Metab. 2021 Oct 5;33(10):1988-2003.e7. doi: 10.1016/j.cmet.2021.07.007. Epub 2021 Jul 29.
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Review: microbial transformations of human bile acids.综述：人胆汁酸的微生物转化
Microbiome. 2021 Jun 14;9(1):140. doi: 10.1186/s40168-021-01101-1.
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Central anorexigenic actions of bile acids are mediated by TGR5.胆汁酸的中枢厌食作用是通过 TGR5 介导的。
Nat Metab. 2021 May;3(5):595-603. doi: 10.1038/s42255-021-00398-4. Epub 2021 May 24.
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Hypothalamic bile acid-TGR5 signaling protects from obesity.下丘脑胆酸-TGR5 信号传递可预防肥胖。
Cell Metab. 2021 Jul 6;33(7):1483-1492.e10. doi: 10.1016/j.cmet.2021.04.009. Epub 2021 Apr 21.
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The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer.法尼醇 X 受体在代谢性疾病、胃肠道癌和肝癌中的作用。
Nat Rev Gastroenterol Hepatol. 2021 May;18(5):335-347. doi: 10.1038/s41575-020-00404-2. Epub 2021 Feb 10.
9
Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice.胃袖状切除术通过减少肠道胆汁酸和脂质吸收改善小鼠代谢。
Proc Natl Acad Sci U S A. 2021 Feb 9;118(6). doi: 10.1073/pnas.2019388118.
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Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice.肌肉特异性 TGR5 过表达可改善葡萄糖耐量受损小鼠的葡萄糖清除率。
J Biol Chem. 2021 Jan-Jun;296:100131. doi: 10.1074/jbc.RA120.016203. Epub 2020 Dec 4.