Department of Cardiology, Tiantai County People's Hospital, Zhejiang, China.
Department of Clinical Epidemiology & Biostatistics, Department of Science and Research, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Clin Invest Med. 2022 Mar 23;45(1):E12-20. doi: 10.25011/cim.v45i1.38083.
To assess the predictive value of SS II (SYNTAX score II) for long-term outcomes in ST-elevated myoarial infarction (STEMI) patients. Source: PubMed, EMBASE and Cochrane databases were searched up until September 24, 2021. Two investigators extracted data independently from the relevant articles. A random-effects model was conducted to combine the pooled hazard ratio (HR) or risk ratio (RR) for association between SS II and long term outcomes. Principal findings: A total of 12 articles (7,195 subjects) were included in the final meta-analyses. Analysis of nine of the articles showed that higher SS II predicted poor long term all-cause mortality among STEMI patients (pooled RRs=4.09,95%CI: 3.49-4.80). A similar association of SS II with poor long term mortality was observed when the crude HRs and adjusted HRs were pooled (crude HRs: pooled HR=1.07, 95%CI: 1.04-1.09; adjusted HRs: pooled HR=1.05, 95%CI:1.04-1.07). The STEMI patients with higher SS II also showed a higher associated with increased risk of long term major adverse cardiac events (pooled HR = 1.05, 95% CI: 1.02-1.07; pooled RR=2.28, 95%CI:2.02-2.57). A consistent association was found for heart failure among STEMI patients. Conclusion: Higher SS II predicted poor long term all-cause mortality, major adverse cardia events and heart failure among STEMI patients.
评估 SS II（SYNTAX 评分 II）对 ST 段抬高型心肌梗死（STEMI）患者长期结局的预测价值。来源：PubMed、EMBASE 和 Cochrane 数据库检索截至 2021 年 9 月 24 日。两名研究者独立从相关文章中提取数据。采用随机效应模型合并 SS II 与长期结局之间关联的合并风险比（HR）或风险比（RR）。主要发现：共有 12 篇文章（7195 例患者）纳入最终的荟萃分析。对 9 篇文章的分析表明，较高的 SS II 预测 STEMI 患者长期全因死亡率较高（合并 RR=4.09，95%CI：3.49-4.80）。当合并原始 HR 和调整 HR 时，也观察到 SS II 与较差的长期死亡率有类似的关联（原始 HRs：合并 HR=1.07，95%CI：1.04-1.09；调整 HRs：合并 HR=1.05，95%CI：1.04-1.07）。SS II 较高的 STEMI 患者发生长期主要不良心脏事件的风险也增加（合并 HR=1.05，95%CI：1.02-1.07；合并 RR=2.28，95%CI：2.02-2.57）。STEMI 患者心力衰竭也存在一致的相关性。结论：较高的 SS II 预测 STEMI 患者长期全因死亡率、主要不良心脏事件和心力衰竭。
