源自光活化亚硝酰锰（II）配合物的一氧化氮递送平台：迈向光药理学。

Nitric oxide delivery platforms derived from a photoactivatable Mn(II) nitrosyl complex: Entry to photopharmacology.

作者信息

Mascharak Pradip K

机构信息

Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.

出版信息

J Inorg Biochem. 2022 Jun;231:111804. doi: 10.1016/j.jinorgbio.2022.111804. Epub 2022 Mar 19.

DOI:10.1016/j.jinorgbio.2022.111804

PMID:35339770

Abstract

The manganese nitrosyl complex derived from a designed pentadentate ligand with one carboxamido group N,N-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-carboxamide (PaPyH; H is the dissociable carboxamide H), namely, [Mn(PaPy)(NO)]ClO (1), serves as an excellent biocompatible source of nitric oxide (NO) when exposed to low power (10-100 mW/cm) visible light. This complex has afforded a series of NO delivery platforms that could find applications in combating chronic infections by drug-resistant bacteria under the control of light.

摘要

由一种设计的具有一个羧酰胺基的五齿配体 N,N-双(2-吡啶甲基)胺-N-乙基-2-吡啶-2-甲酰胺(PaPyH；H 是可解离的羧酰胺氢)衍生出的亚硝酰锰配合物，即[Mn(PaPy)(NO)]ClO₄ (1)，在暴露于低功率(10 - 100 mW/cm²)可见光时，可作为一种出色的生物相容性一氧化氮(NO)源。该配合物提供了一系列 NO 递送平台，这些平台可用于在光控下对抗耐药细菌引起的慢性感染。