Liu Weiwei, Semcheddine Farouk, Guo Zengchao, Jiang Hui, Wang Xuemei
State Key Laboratory of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China.
Nanomaterials (Basel). 2022 Apr 14;12(8):1348. doi: 10.3390/nano12081348.
Cancer is still one of the major health issues faced by human beings today. Various nanomaterials have been designed to treat tumors and have made great progress. Herein, we used amino-functionalized metal organic framework (UiO-66-NH) as superior templates and successfully synthesized the UiO-66-NH@Au composite nanoparticles (UA) with high loading capacity and excellent photothermal properties through a simple and gentle method. In addition, due to the rich pore structure and excellent biocompatibility of the as-prepared composite nanoparticles, the hydrophobic NO donor BNN6 (N,N'-Di-sec-butyl-N,N'-dinitroso-1, 4-phenylenediamine) molecule was efficiently delivered. Based on the phenomenon where BNN6 molecules can decompose and release NO at high temperature, when UiO-66-NH@Au-BNN6 composite nanoparticles (UA-BNN6) entered tumor cells and were irradiated by NIR, the porous gold nanoshells on the surface of composite nanoparticles induced an increase in temperature through the photothermal conversion process and promoted the decomposition of BNN6 molecules, releasing high concentration of NO, thus efficiently killing HeLa cells through the synergistic effect of NO-photothermal therapy. This effective, precise and safe treatment strategy controlled by NIR laser irradiation represents a promising alternative in the field of cancer treatment.
癌症仍然是当今人类面临的主要健康问题之一。人们设计了各种纳米材料来治疗肿瘤，并取得了很大进展。在此，我们使用氨基功能化金属有机框架（UiO-66-NH）作为优良模板，通过一种简单温和的方法成功合成了具有高负载能力和优异光热性能的UiO-66-NH@Au复合纳米粒子（UA）。此外，由于所制备的复合纳米粒子具有丰富的孔结构和优异的生物相容性，疏水性NO供体BNN6（N，N'-二仲丁基-N，N'-二亚硝基-1，4-苯二胺）分子被有效地递送。基于BNN6分子在高温下可分解并释放NO的现象，当UiO-66-NH@Au-BNN6复合纳米粒子（UA-BNN6）进入肿瘤细胞并受到近红外光照射时，复合纳米粒子表面的多孔金纳米壳通过光热转换过程诱导温度升高，促进BNN6分子分解，释放高浓度的NO，从而通过NO-光热疗法的协同作用有效杀死HeLa细胞。这种由近红外激光照射控制的有效、精确且安全的治疗策略在癌症治疗领域代表了一种有前景的替代方法。
