Mu Guang, Zhang Wenhao, Huang Jingjing, Chen Zhipeng, Wang Jun
Department of Thoracic Surgery, The First Clinical Medical College of Nanjing Medical University, Nanjing 210000, China.
Zhongguo Fei Ai Za Zhi. 2022 Mar 20;25(3):207-213. doi: 10.3779/j.issn.1009-3419.2022.101.04.
Cancer-associated fibroblasts (CAFs) and tumor-infiltrating immune cells are the most essential components of the tumor microenvironment (TME). They communicate with each other in tumor microenvironment and play a critical role in tumorigenesis and development. CAFs are very heterogeneous and different subtypes of CAFs display different functions. At the same time, it can contribute to the regulation of the function of tumor-infiltrating immune cells and eventually result in the carcinogenesis, tumor progression, invasion, metastasis and other biological behaviors of tumors by producting various growth factors and cytokines etc. Based on the current research results at home and abroad, this paper reviews the recent research progress on the regulation of CAFs on infiltrating immune cells in tumor microenvironment. .
癌症相关成纤维细胞（CAFs）和肿瘤浸润免疫细胞是肿瘤微环境（TME）的最重要组成部分。它们在肿瘤微环境中相互交流，在肿瘤发生和发展中起关键作用。CAFs具有高度异质性，不同亚型的CAFs发挥不同功能。同时，它可通过产生各种生长因子和细胞因子等，促进对肿瘤浸润免疫细胞功能的调节，最终导致肿瘤的致癌作用、肿瘤进展、侵袭、转移及其他生物学行为。基于国内外目前的研究成果，本文综述了肿瘤微环境中CAFs对浸润免疫细胞调节作用的最新研究进展。
