Department of Ophthalmology, Shanxi Province Fenyang Hospital, Fenyang, 032200, Shanxi Province, People's Republic of China.
Department of Ophthalmology, Shanxi Datong University, Datong, 037000, Shanxi Province, People's Republic of China.
Drug Des Devel Ther. 2022 Mar 21;16:749-757. doi: 10.2147/DDDT.S352876. eCollection 2022.
Open-angle glaucoma is a common ophthalmic disease, which has a great impact on the vision of middle-aged and elderly people. Medication plays an important role in the treatment of glaucoma, so finding effective drug treatment is of great significance to improve the quality of life of glaucoma patients.
To explore the curative effect of nimodipine combined with latanoprost in the treatment of open-angle glaucoma and its effect on ocular hemodynamics and visual field defects.
This study retrospectively analyzed the clinical data of 87 patients with open-angle glaucoma who came to the Shanxi Province Fenyang Hospital and The First Affiliated Hospital of Shanxi Datong University for treatment from January 2019 to January 2021. According to different treatment plans, the patients were divided into two groups: an observation group (n = 46) treated with nimodipine combined with latanoprost, and a control group (n = 41) treated by latanoprost monotherapy. Treatment efficacy, hemodynamics, visual field defects, 24-hour peak intraocular pressure, binocular optic disc parameters, adverse reactions and quality of life were recorded and compared between two groups of patients.
The overall therapeutic effect of the observation group was significantly better than that in the control group. After treatment, ocular hemodynamics, visual field defects, 24-hour peak intraocular pressure, binocular optic disc parameters and life quality of both groups were obviously improved compared to those before treatment, with more significant improvements in the observation group. In addition, there was no significant difference in the incidence of adverse reactions between the two groups.
Nimodipine combined with latanoprost eye drops is effective in the treatment of primary open-angle glaucoma, which could effectively improve the ocular hemodynamics and visual field defects of patients with fewer adverse reactions and higher safety. Therefore, it can be further promoted and used in clinical practice.
开角型青光眼是一种常见的眼科疾病，对中老年人的视力影响较大。药物治疗在青光眼的治疗中起着重要作用，因此寻找有效的药物治疗方法对于提高青光眼患者的生活质量具有重要意义。
探讨尼莫地平联合拉坦前列素治疗开角型青光眼的疗效及其对眼血流动力学和视野缺损的影响。
本研究回顾性分析了 2019 年 1 月至 2021 年 1 月山西省汾阳医院和山西大同大学第一附属医院收治的 87 例开角型青光眼患者的临床资料。根据不同的治疗方案将患者分为观察组（n=46）和对照组（n=41），观察组给予尼莫地平联合拉坦前列素治疗，对照组给予拉坦前列素单药治疗。记录并比较两组患者的治疗效果、血流动力学、视野缺损、24 小时眼压峰值、双眼视盘参数、不良反应及生活质量。
观察组总有效率明显优于对照组。治疗后两组患者的眼血流动力学、视野缺损、24 小时眼压峰值、双眼视盘参数及生活质量均明显优于治疗前，观察组改善更明显。此外，两组不良反应发生率无显著差异。
尼莫地平联合拉坦前列素滴眼液治疗原发性开角型青光眼疗效显著，能有效改善患者的眼血流动力学和视野缺损，不良反应少，安全性高，可在临床进一步推广应用。
