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一名非肝硬化肝脏中患有乙型肝炎表面抗原阳性多灶性肝细胞癌青少年的病例报告。

A case report of a teenager with hepatitis B surface antigen-positive multifocal hepatocellular carcinoma in a noncirrhotic liver.

作者信息

Danso Kwadwo Apeadu, Akuaku Rosemary Sefakor, Taylor Rebekah Ruth, Amoako Emmanuella, Ulzen-Appiah Kofi, Jimah Bashiru Babatunde, Tagoe Lily Gloria

机构信息

Department of Paediatrics and Child Health Cape Coast Teaching Hospital Cape Coast Ghana.

School of Medical Sciences University of Cape Coast Cape Coast Ghana.

出版信息

Clin Case Rep. 2022 Mar 20;10(3):e05622. doi: 10.1002/ccr3.5622. eCollection 2022 Mar.

DOI:10.1002/ccr3.5622
PMID:35340653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8935124/
Abstract

Hepatitis B virus is a known carcinogen for hepatocellular carcinoma, which is rare in the pediatric population. We report a 13-year-old patient with hepatitis B surface antigen-positive multifocal hepatocellular carcinoma in a noncirrhotic liver. Her APRI score was 0.24. Her BCLC stage was C, and her caregiver opted for palliative care.

摘要

乙型肝炎病毒是一种已知的肝细胞癌致癌物，在儿童人群中较为罕见。我们报告一名13岁的患者，其非肝硬化肝脏中出现乙型肝炎表面抗原阳性的多灶性肝细胞癌。她的APRI评分是0.24。她的BCLC分期为C期，其护理人员选择了姑息治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac09/8935124/86ae392b85e9/CCR3-10-e05622-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac09/8935124/22b387a1fa2c/CCR3-10-e05622-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac09/8935124/86ae392b85e9/CCR3-10-e05622-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac09/8935124/22b387a1fa2c/CCR3-10-e05622-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac09/8935124/86ae392b85e9/CCR3-10-e05622-g002.jpg

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本文引用的文献

1
BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update.BCLC 策略用于预后预测和治疗推荐：2022 年更新版。
J Hepatol. 2022 Mar;76(3):681-693. doi: 10.1016/j.jhep.2021.11.018. Epub 2021 Nov 19.
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Hepatocellular carcinoma in children: hepatic resection and liver transplantation.儿童肝细胞癌：肝切除与肝移植
Transl Gastroenterol Hepatol. 2018 Sep 10;3:59. doi: 10.21037/tgh.2018.09.05. eCollection 2018.
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Hepatitis B At-Birth Dose Vaccine: An Urgent Call for Implementation in Ghana.乙肝出生剂量疫苗：呼吁在加纳紧急实施
Vaccines (Basel). 2018 Mar 12;6(1):15. doi: 10.3390/vaccines6010015.
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Hepatocellular Carcinoma: Current Concepts in Diagnosis, Staging and Treatment.肝细胞癌：诊断、分期与治疗的当前概念
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Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients.评价 APRI 和 FIB-4 评分系统在慢性乙型肝炎患者肝纤维化无创评估中的应用。
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Impact of Vitamin K Administration on INR Changes and Bleeding Events Among Patients With Cirrhosis.维生素K给药对肝硬化患者国际标准化比值（INR）变化及出血事件的影响
Ann Pharmacother. 2016 Feb;50(2):113-7. doi: 10.1177/1060028015617277. Epub 2015 Nov 18.
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Biomarkers for the early diagnosis of hepatocellular carcinoma.肝细胞癌早期诊断的生物标志物。
World J Gastroenterol. 2015 Oct 7;21(37):10573-83. doi: 10.3748/wjg.v21.i37.10573.
8
Role of the Aspartate Transaminase and Platelet Ratio Index in Assessing Hepatic Fibrosis and Liver Inflammation in Adolescent Patients with HBeAg-Positive Chronic Hepatitis B.天冬氨酸转氨酶与血小板比值指数在评估HBeAg阳性慢性乙型肝炎青少年患者肝纤维化和肝脏炎症中的作用
Gastroenterol Res Pract. 2015;2015:906026. doi: 10.1155/2015/906026. Epub 2015 Jul 5.
9
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