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盐酸罗匹尼罗治疗帕金森病的临床观察。

Clinical Observation of Ropinirole Hydrochloride in the Treatment of Parkinson's Disease.

机构信息

Chongqing Chemical Industry Vocational College, Changshou, 401220 Chongqing, China.

出版信息

Comput Math Methods Med. 2022 Mar 17;2022:3989770. doi: 10.1155/2022/3989770. eCollection 2022.

DOI:10.1155/2022/3989770
PMID:35341012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8947903/
Abstract

Parkinson's disease is a degenerative disease of the nervous system, which is more common in middle-aged and elderly people. Currently, the incidence of PD is increasing. The disease is a degenerative disease, which is irreversible and requires life-long treatment. Ropinirole hydrochloride can also be used for Parkinson's disease. Therefore, this article conducted research on this; the purpose is to further determine whether the drug can be used for Parkinson's disease. The method used in this article is a method of quantitative analysis and experimental testing. This article selects Parkinson's disease patients from the provincial hospital to conduct investigations and group experiments on these people to test the effects of different levels of ropinirole hydrochloride in the treatment of Parkinson's disease. Experimental data showed that when the dose of ropinirole was 1 mg, its peak concentration reached 24.95 and the clearance rate reached 143.42. This shows that, in the early stage of medication, it has certain benefits in disease control.

摘要

帕金森病是一种神经系统退行性疾病,多见于中老年人。目前 PD 的发病率呈上升趋势。该疾病是一种退行性疾病,不可逆转,需要终身治疗。盐酸罗匹尼罗也可用于治疗帕金森病。因此,本文对此进行了研究;目的是进一步确定该药物是否可用于帕金森病。本文采用的方法是定量分析和实验测试的方法。本文从省医院选取帕金森病患者,对这些人进行调查和分组实验,以测试不同水平的盐酸罗匹尼罗在帕金森病治疗中的效果。实验数据表明,当罗匹尼罗的剂量为 1mg 时,其峰浓度达到 24.95,清除率达到 143.42。这表明,在早期用药阶段,它在控制疾病方面具有一定的益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1775/8947903/ab26c499dd7c/CMMM2022-3989770.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1775/8947903/5020e73b87b4/CMMM2022-3989770.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1775/8947903/57cef713abb5/CMMM2022-3989770.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1775/8947903/3b569d67299e/CMMM2022-3989770.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1775/8947903/ab26c499dd7c/CMMM2022-3989770.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1775/8947903/5020e73b87b4/CMMM2022-3989770.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1775/8947903/57cef713abb5/CMMM2022-3989770.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1775/8947903/3b569d67299e/CMMM2022-3989770.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1775/8947903/ab26c499dd7c/CMMM2022-3989770.004.jpg

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JAMA. 2021 Sep 14;326(10):926-939. doi: 10.1001/jama.2021.10207.
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A critical review of apomorphine hydrochloride sublingual film for the treatment of Parkinson's disease 'OFF' episodes.盐酸阿扑吗啡舌下膜治疗帕金森病“关”期发作的批判性综述
Expert Rev Neurother. 2021 Feb;21(2):169-177. doi: 10.1080/14737175.2020.1855145. Epub 2020 Dec 6.
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Treatment of depression in Parkinson's disease.
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Phytotherapy in treatment of Parkinson's disease: a review.植物疗法治疗帕金森病:综述。
Pharm Biol. 2019 Dec;57(1):355-362. doi: 10.1080/13880209.2019.1618344.
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[Characteristics of levodopa treatment in advanced Parkinson's disease in the experiences of the neurology clinics of Târgu Mureș, Romania].[罗马尼亚特尔古穆列什神经病学诊所经验中晚期帕金森病左旋多巴治疗的特点]
Orv Hetil. 2019 Apr;160(17):662-669. doi: 10.1556/650.2019.31354.
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Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease.香芹酚长期治疗可改善帕金森病大鼠模型的被动回避记忆。
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