药物治疗在儿童分泌性中耳炎管理中的作用：系统评价和荟萃分析。
Pharmacotherapy focusing on for the management of otitis media with effusion in children: Systematic review and meta-analysis.
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Tohoku University School of Medicine.
Department of Otorhinolaryngology, Head and Neck Surgery, Kansai Medcal University.
出版信息
Auris Nasus Larynx. 2022 Oct;49(5):748-754. doi: 10.1016/j.anl.2022.03.017. Epub 2022 Mar 24.
OBJECTIVE
To examine the evidence for treating children with otitis media with effusion with pharmacotherapy.
DATA SOURCES
For the systematic review, data were retrieved from PubMed, Cochrane database, and the Japan Medical Abstracts Society Database (1st January 1995 through 31th May 2019).
STUDY SELECTION
Articles addressing pharmacotherapy for the management of otitis media with effusion in children were selected in English.
DATA EXTRACTION
The database was searched using the keywords "Otitis Media with effusion or secretory otitis media" and the following medical agents: carbocysteine, antihistamines, leukotriene receptor antagonist, and steroid nasal spray.
DATA SYNTHESIS
After a critical review of 18 studies, studies addressing steroid nasal spray were eligible for quantitative synthesis. Intranasal steroids for OME showed no benefit with OR 1.155 (95% CI 0.834-1.598) within one month. Conversely, intranasal steroids have effects for OME with OR 1.858 (95% CI 1.240-2.786) for more than one month.
CONCLUSIONS
We found evidence of benefit from treatment of OME in children with intranasal steroids and S-carboxymethylcysteine at longer-term follow-up.
目的
研究药物治疗分泌性中耳炎（OME）患儿的证据。
资料来源
为了进行系统评价，从 PubMed、Cochrane 数据库和日本医学文摘协会数据库（1995 年 1 月 1 日至 2019 年 5 月 31 日）检索数据。
研究选择
选择了用英语发表的关于药物治疗儿童 OME 的文章。
数据提取
使用关键词“Otitis Media with effusion or secretory otitis media”和以下医学药物：半胱氨酸羧甲基、抗组胺药、白三烯受体拮抗剂和皮质类固醇鼻喷雾剂，在数据库中搜索。
数据综合
在对 18 项研究进行严格审查后，研究皮质类固醇鼻喷雾剂的研究符合定量综合的条件。皮质类固醇鼻喷雾剂治疗 OME 在一个月内的 OR 为 1.155（95%CI 0.834-1.598），无明显获益。相反，皮质类固醇鼻喷雾剂在一个月以上治疗 OME 的效果 OR 为 1.858（95%CI 1.240-2.786）。
结论
我们发现，在长期随访中，儿童使用皮质类固醇和 S-羧甲基半胱氨酸治疗 OME 有获益的证据。
Zotero 插件