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早期生活应激对冲动性的影响。

The effects of early life stress on impulsivity.

机构信息

Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA 19122, USA.

出版信息

Neurosci Biobehav Rev. 2022 Jun;137:104638. doi: 10.1016/j.neubiorev.2022.104638. Epub 2022 Mar 24.

DOI:10.1016/j.neubiorev.2022.104638
PMID:35341796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9119952/
Abstract

Elevated impulsivity is a symptom shared by various psychiatric disorders such as substance use disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. However, impulsivity is not a unitary construct and impulsive behaviors fall into two subcategories: impulsive action and impulsive choice. Impulsive choice refers to the tendency to prefer immediate, small rewards over delayed, large rewards, whereas impulsive action involves difficulty inhibiting rash, premature, or mistimed behaviors. These behaviors are mediated by the mesocorticolimbic dopamine (DA) system, which consists of projections from the ventral tegmental area to the nucleus accumbens and prefrontal cortex. Early life stress (ELS) alters both impulsive choice and impulsive action in rodents. ELS also changes DA receptor expression, transmission, and activity within the mesocorticolimbic system. This review integrates the dopamine, impulsivity, and ELS literature to provide evidence that ELS alters impulsivity via inducing changes in the mesocorticolimbic DA system. Understanding how ELS affects brain circuits associated with impulsivity can help advance treatments aimed towards reducing impulsivity symptoms in a variety of psychiatric disorders.

摘要

冲动性升高是物质使用障碍、双相情感障碍和注意缺陷/多动障碍等各种精神疾病共有的症状。然而，冲动性不是一个单一的结构，冲动行为分为两个亚类：冲动行为和冲动选择。冲动选择是指倾向于选择即时的、小的奖励，而不是延迟的、大的奖励，而冲动行为涉及到难以抑制轻率、过早或不合时宜的行为。这些行为由中脑边缘多巴胺（DA）系统介导，该系统由腹侧被盖区到伏隔核和前额叶皮层的投射组成。早期生活应激（ELS）改变了啮齿动物的冲动选择和冲动行为。ELS 还改变了中脑边缘 DA 系统中的 DA 受体表达、传递和活性。这篇综述整合了多巴胺、冲动性和 ELS 的文献，提供了证据表明 ELS 通过改变中脑边缘 DA 系统来改变冲动性。了解 ELS 如何影响与冲动性相关的大脑回路，可以帮助推进针对各种精神疾病减少冲动性症状的治疗方法。

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[1]
The effects of early life stress on impulsivity.

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[2]
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[4]
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[6]
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[7]
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引用本文的文献

[1]
Involvement of a stress-responsive orbito-striatal projection in impulsive action in male rats.

Int J Neuropsychopharmacol. 2025-7-23

[2]
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JAACAP Open. 2024-3-8

[3]
Emerging role of microglia in the developing dopaminergic system: perturbation by early life stress.

Neural Regen Res. 2024-11-13

[4]
Effects of chronic stress on cognitive function - From neurobiology to intervention.

Neurobiol Stress. 2024-9-2

[5]
A mixed methods experience sampling study of a posttraumatic growth model for addiction recovery.

Sci Rep. 2024-2-21

[6]
Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with or without perineuronal nets.

Neurobiol Stress. 2023-5-29

[7]
Early-life stress affects Mongolian gerbil interactions with conspecific vocalizations in a sex-specific manner.

Front Behav Neurosci. 2023-5-10

[8]
Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress.

Addict Neurosci. 2023-6

[9]
Distinct neuronal excitability alterations of medial prefrontal cortex in early-life neglect model of rats.

Animal Model Exp Med. 2022-6

本文引用的文献

[1]
Control of impulsivity by G-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex.

Commun Biol. 2021-6-2

[2]
Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes.

Proc Natl Acad Sci U S A. 2021-2-23

[3]
Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice.

Brain Res. 2021-3-15

[4]
Early life stress-induced alterations in the activity and morphology of ventral tegmental area neurons in female rats.

Neurobiol Stress. 2020-9-3

[5]
Sex differences in dopamine release regulation in the striatum.

Neuropsychopharmacology. 2021-2

[6]
The hypodopaminergic state ten years after: transcranial magnetic stimulation as a tool to test the dopamine hypothesis of drug addiction.

Curr Opin Pharmacol. 2021-2

[7]
Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats.

Front Neuroanat. 2020-10-23

[8]
The effects of early life stress on motivated behaviors: A role for gonadal hormones.

Neurosci Biobehav Rev. 2020-12

[9]
Long-term Neighborhood Effects on Adolescent Outcomes: Mediated through Adverse Childhood Experiences and Parenting Stress.

J Youth Adolesc. 2020-8-17

[10]
Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons.

Proc Natl Acad Sci U S A. 2020-7-21

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