Department of Biomedical Sciences, Sect. of Physiology, University of Cagliari, Italy.
Department of Biomedical Sciences, Sect. of Physiology, University of Cagliari, Italy.
Behav Brain Res. 2022 Jun 3;427:113860. doi: 10.1016/j.bbr.2022.113860. Epub 2022 Mar 24.
Among the factors that contribute to the physiological variability of the olfactory function of individuals, an important role seems to be played by the OBPs present in the mucus that bathes the ciliated terminals of the olfactory sensory neurons, facilitating the access of odorants to the olfactory receptors. It was recently highlighted that the rs2590498 polymorphism in the odor binding-protein (OBPIIa) gene it is associated with the olfactory threshold in healthy individuals. Aim of this study was to evaluate: 1) the presence of a relationship between the threshold olfactory performance of healthy subjects and the intensity with which they perceive the smelled odorants, and 2) the effect of the rs2590498 polymorphism of the OBPIIa gene on perceived intensity. We found a positive correlation between threshold olfactory and perceived intensity, and that AA homozygous subjects reported a perceived intensity higher than heterozygous and GG homozygous subjects. By showing a positive effect of the rs2590498 polymorphism of the hOBPIIa gene on the intensity perceived, these results suggest that it allows a larger number of molecules in an odorous mixture to reach the olfactory receptors.
在导致个体嗅觉功能生理变异性的因素中，存在于覆盖嗅感觉神经元纤毛末端的黏液中的嗅蛋白（OBP）似乎起着重要作用，这有助于气味物质进入嗅觉受体。最近有研究强调，嗅觉结合蛋白（OBPIIa）基因中的 rs2590498 多态性与健康个体的嗅觉阈值有关。本研究旨在评估：1）健康受试者的嗅觉阈值表现与他们感知气味的强度之间是否存在关系，以及 2）OBPIIa 基因的 rs2590498 多态性对感知强度的影响。我们发现嗅觉阈值与感知强度之间存在正相关关系，并且 AA 纯合子受试者报告的感知强度高于杂合子和 GG 纯合子受试者。这些结果表明，hOBPIIa 基因的 rs2590498 多态性对感知强度有积极影响，表明它允许更多的气味混合物分子到达嗅觉受体。
