干燥综合征患者的类癌性血管炎经甲氨蝶呤治疗成功
Livedoid Vasculitis in a Patient With Sjogren Syndrome Successfully Treated With Methotrexate.
作者信息
Aldehaim Abdulkarim Yousef, Alarfaj Abdurhman Saud
机构信息
Unit of Rheumatology, Department of Medicine, King Saud University, Riyadh, Saudi Arabia.
出版信息
Clin Med Insights Case Rep. 2022 Mar 21;15:11795476221088489. doi: 10.1177/11795476221088489. eCollection 2022.
INTRODUCTION
Cutaneous vasculitis occurs in a sizable minority of patients with Sjogren syndrome. In addition, their response to different modalities of therapy is variable.
CASE DESCRIPTION
We present a case of a 66-year-old female with Sjogren syndrome cutaneous vasculitis in whom combination treatment with Rituximab and Azathioprine failed to show a favorable response. However, methotrexate proved to be an excellent alternative.
DISCUSSION
In cutaneous vasculitis, in addition to the necessary local therapy applied to the affected limbs, methotrexate produced a complete response when other treatment modalities failed. Therefore, it may be advisable to use methotrexate to treat cutaneous vasculitis before trying Rituximab.
CONCLUSION
In cutaneous vasculitis associated with Sjogren syndrome, methotrexate can be an early effective therapeutic strategy.
引言
相当一部分干燥综合征患者会出现皮肤血管炎。此外，他们对不同治疗方式的反应各不相同。
病例描述
我们报告一例66岁患有干燥综合征皮肤血管炎的女性病例，利妥昔单抗和硫唑嘌呤联合治疗未能显示出良好疗效。然而，甲氨蝶呤被证明是一种极佳的替代药物。
讨论
在皮肤血管炎中，除了对受影响肢体进行必要的局部治疗外，当其他治疗方式无效时，甲氨蝶呤可产生完全缓解。因此，在尝试使用利妥昔单抗之前，使用甲氨蝶呤治疗皮肤血管炎可能是明智的。
结论
在与干燥综合征相关的皮肤血管炎中，甲氨蝶呤可以是一种早期有效的治疗策略。
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