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Estrogen Receptors in Colorectal Cancer: Facts, Novelties and Perspectives.结直肠癌中的雌激素受体：事实、新进展和展望。
Curr Oncol. 2021 Oct 20;28(6):4256-4263. doi: 10.3390/curroncol28060361.
2
Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers.激素敏感性癌症中膜甾体受体的分子特征。
Cells. 2021 Nov 3;10(11):2999. doi: 10.3390/cells10112999.
3
Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis.绝经后女性内源性循环性激素浓度与结肠癌风险：一项前瞻性研究和荟萃分析。
JNCI Cancer Spectr. 2021 Sep 28;5(6). doi: 10.1093/jncics/pkab084. eCollection 2021 Dec.
4
Exploring the Biological Activity and Mechanism of Xenoestrogens and Phytoestrogens in Cancers: Emerging Methods and Concepts.探讨外源性雌激素和植物雌激素在癌症中的生物学活性和作用机制：新兴方法和概念。
Int J Mol Sci. 2021 Aug 16;22(16):8798. doi: 10.3390/ijms22168798.
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Colorectal cancer incidence and mortality: the current status, temporal trends and their attributable risk factors in 60 countries in 2000-2019.2000-2019 年 60 个国家结直肠癌发病率和死亡率：现状、时间趋势及其归因危险因素。
Chin Med J (Engl). 2021 Jul 7;134(16):1941-1951. doi: 10.1097/CM9.0000000000001619.
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Prediagnostic use of estrogen-only therapy is associated with improved colorectal cancer survival in menopausal women: a Swedish population-based cohort study.绝经后女性使用仅雌激素治疗与改善结直肠癌生存相关：一项瑞典基于人群的队列研究。
Acta Oncol. 2021 Jul;60(7):881-887. doi: 10.1080/0284186X.2021.1909747. Epub 2021 Apr 16.
7
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
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8
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Int J Mol Sci. 2021 Jan 27;22(3):1253. doi: 10.3390/ijms22031253.
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10
Randomized Trial Evaluation of the Benefits and Risks of Menopausal Hormone Therapy Among Women 50-59 Years of Age.50-59 岁女性绝经激素治疗的获益与风险的随机临床试验评估。
Am J Epidemiol. 2021 Feb 1;190(3):365-375. doi: 10.1093/aje/kwaa210.

雌激素参与结直肠癌发病机制的研究现状

Actualities in Involvement of Estrogens in the Pathogenesis of Colorectal Cancer.

作者信息

Anghel R M, Serbanescu G L

机构信息

"Carol Davila" University of Medicine and Pharmacy, Faculty of General Medicine, Bucharest, Romania.

Institute of Oncology, Bucharest, Romania.

出版信息

Acta Endocrinol (Buchar). 2021 Jul-Sep;17(3):422-425. doi: 10.4183/aeb.2021.422.

DOI:10.4183/aeb.2021.422
PMID:35342472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8919495/
Abstract

Gastrointestinal effects of estrogens are emerging as an important topic in colorectal cancer management. Current research demonstrated the link between inflammation and this malignancy, so important estrogen dependent mediators of the inflammatory response have been identified. Radioresistance and chemoresistance still represent an important cause of therapeutic failure in colorectal cancer and lead to further studies of colorectal carcinogenesis and predictive markers.

摘要

雌激素对胃肠道的影响正成为结直肠癌治疗中的一个重要课题。目前的研究表明炎症与这种恶性肿瘤之间存在联系，因此已确定了炎症反应中重要的雌激素依赖性介质。放射抗性和化学抗性仍然是结直肠癌治疗失败的一个重要原因，并促使人们对结直肠癌发生机制和预测标志物进行进一步研究。