Hatırnaz Şafak, Hatırnaz Ebru Saynur, Ellibeş Kaya Aşkı, Hatırnaz Kaan, Soyer Çalışkan Canan, Sezer Özlem, Dokuzeylül Güngor Nur, Demirel Cem, Baltacı Volkan, Tan Seang, Dahan Michael
Medicana Samsun International Hospital, In Vitro Fertilization-In Vitro Maturation Unit, Samsun, Turkey.
Private Office, Clinic of Obstetrics and Gynecology Specialist, Samsun, Turkey.
Turk J Obstet Gynecol. 2022 Mar 28;19(1):60-80. doi: 10.4274/tjod.galenos.2022.76329.
A small proportion of infertile women experience repeated oocyte maturation abnormalities (OMAS). OMAS include degenerated and dysmorphic oocytes, empty follicle syndrome, oocyte maturation arrest (OMA), resistant ovary syndrome and maturation defects due to primary ovarian insufficiency. Genetic factors play an important role in OMAS but still need specifications. This review documents the spectrum of OMAS and to evaluate the multiple subtypes classified as OMAS. In this review, readers will be able to understand the oocyte maturation mechanism, gene expression and their regulation that lead to different subtypes of OMAs, and it will discuss the animal and human studies related to OMAS and lastly the treatment options for OMAs. Literature searches using PubMed, MEDLINE, Embase, National Institute for Health and Care Excellence were performed to identify articles written in English focusing on Oocyte Maturation Abnormalities by looking for the following relevant keywords. A search was made with the specified keywords and included books and documents, clinical trials, animal studies, human studies, meta-analysis, randomized controlled trials, reviews, systematic reviews and options written in english. The search detected 3,953 sources published from 1961 to 2021. After title and abstract screening for study type, duplicates and relevancy, 2,914 studies were excluded. The remaining 1,039 records were assessed for eligibility by full-text reading and 886 records were then excluded. Two hundred and twenty seven full-text articles and 0 book chapters from the database were selected for inclusion. Overall, 227 articles, one unpublished and one abstract paper were included in this final review. In this review study, OMAS were classified and extensively evaluatedand possible treatment options under the light of current information, present literature and ongoing studies. Either genetic studies or in vitro maturation studies that will be handled in the future will lead more informations to be reached and may make it possible to obtain pregnancies.
一小部分不孕女性会反复出现卵母细胞成熟异常（OMAS）。OMAS包括退化和形态异常的卵母细胞、空卵泡综合征、卵母细胞成熟停滞（OMA）、卵巢抵抗综合征以及原发性卵巢功能不全导致的成熟缺陷。遗传因素在OMAS中起重要作用，但仍需明确。本综述记录了OMAS的范围，并评估了归类为OMAS的多种亚型。在本综述中，读者将能够了解导致不同亚型OMA的卵母细胞成熟机制、基因表达及其调控，并将讨论与OMAS相关的动物和人体研究，最后探讨OMA的治疗选择。通过使用PubMed、MEDLINE、Embase、英国国家卫生与临床优化研究所进行文献检索，通过查找以下相关关键词来识别以英文撰写的关注卵母细胞成熟异常的文章。使用指定关键词进行搜索，包括书籍和文献资料、临床试验、动物研究、人体研究、荟萃分析、随机对照试验、综述、系统评价以及英文撰写的观点。搜索发现了1961年至2021年发表的3953篇文献来源。在对研究类型、重复项和相关性进行标题和摘要筛选后，排除了2914项研究。通过全文阅读对其余1039条记录进行资格评估，随后又排除了886条记录。从数据库中选择了227篇全文文章和0篇书籍章节纳入。总体而言，本最终综述纳入了227篇文章、1篇未发表文章和1篇摘要论文。在本综述研究中，根据当前信息、现有文献和正在进行的研究对OMAS进行了分类和广泛评估，并探讨了可能的治疗选择。未来进行的遗传研究或体外成熟研究将带来更多信息，可能使怀孕成为可能。
