Turk Psikiyatri Derg. 2022 Spring;33(1):70-72. doi: 10.5080/u25787.
Many case reports have demonstrated that using antidepressants and especially the selective serotonin reuptake inhibitors (SSRIs), and the noradrenergic and specific serotonergic antidepresants mirtazapine and mianserin can lead to restless legs syndrome (RLS). However, there are disagreements in the results of the limited number of investigations on the relationship of RLS with antidepressants. Trazodone is a frequently used antidepressant with complex agonistic/antagonistic effects on the serotonergic system and moderate blockage on the histamine receptor. This report dicusses the case of a 39-year old female patient who developed RLS after using trazodone (100mg/day) prescribed by her pscyhiatrist for treating her insomnia complaints. We have learned from the patient's statement that she felt burning, tingling and restlessness in her legs, that started from the first night of the treatment and caused an urge to move her legs. The effects were attributed to trazodone and the treatment was discontinued. The patient reported at her control examination the disappearance of RLS symptoms one day after discontinuing trazodone use and the complete improvement of her insomnia complaints.
许多病例报告表明，使用抗抑郁药，特别是选择性 5-羟色胺再摄取抑制剂（SSRIs），以及去甲肾上腺素和特异性 5-羟色胺抗抑郁药米氮平和米安色林，会导致不宁腿综合征（RLS）。然而，关于 RLS 与抗抑郁药之间关系的为数不多的研究结果存在分歧。曲唑酮是一种常用的抗抑郁药，对 5-羟色胺系统具有复杂的激动/拮抗作用，对组胺受体具有中度阻断作用。本报告讨论了一位 39 岁女性患者的病例，她因失眠症接受精神科医生开的曲唑酮（100mg/天）治疗后出现 RLS。我们从患者的陈述中了解到，她的腿部开始出现烧灼感、刺痛感和不安感，从治疗的第一晚开始，导致她迫切想要移动腿部。这些症状归因于曲唑酮，因此停止了治疗。患者在复诊时报告，停用曲唑酮一天后 RLS 症状消失，失眠症状完全改善。
