铜催化的末端炔烃的 -选择性自由基 1,2-芳基烷基化反应。
Copper-Catalyzed -Selective Radical 1,2-Alkylarylation of Terminal Alkynes.
机构信息
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518071, China.
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
出版信息
Org Lett. 2022 Apr 8;24(13):2536-2540. doi: 10.1021/acs.orglett.2c00692. Epub 2022 Mar 28.
A copper-catalyzed highly -selective radical 1,2-alkylarylation of terminal alkynes with aryl boronic acids and alkyl bromides has been established. The reaction exhibits high compatibility with a wide range of terminal alkynes and diverse aryl boronic acids, thus providing facile access to various stereodefined trisubstituted alkenes in high yield under mild reaction conditions. Preliminary mechanistic investigations support the formation of alkyl radicals and their subsequent addition to alkynes in the reaction.
铜催化的末端炔烃与芳基硼酸和溴代烷烃的高选择性自由基 1,2-烷基芳基化反应已经建立。该反应与广泛的末端炔烃和各种芳基硼酸具有很高的相容性，因此在温和的反应条件下能够以高产率简便地获得各种立体定义的三取代烯烃。初步的机理研究支持了反应中烷基自由基的形成及其随后与炔烃的加成。
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