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[中国65岁及以上老年人睡眠时间与认知障碍关联的队列研究]

[A cohort study of association between sleep duration and cognitive impairment in the elderly aged 65 years and older in China].

作者信息

Wei Y, Lin J L, Chen G, Pei L J

机构信息

Institute of Population Research/Chinese Center for Population Health and Development, Peking University, Beijing 100871, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2022 Mar 10;43(3):359-365. doi: 10.3760/cma.j.cn112338-20210410-00305.

Abstract

To explore the effect of sleep duration on the risk of cognitive impairment in the elderly in China. Baseline data of 9 679 elderly individuals with intact cognition were collected from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2005, and followed up was conducted until 2018. Cox proportional hazards model was used to analyze the association between different sleep durations and the risk for cognitive impairment in the elderly. Compared with elderly with sleep duration of 6 hours per day, those with sleep duration less than 5 hours had increased risk for cognitive impairment by 30% (=1.30, 95%: 1.05-1.62), and those with sleep durations of 7 hours, 8 hours and more than 9 hours had increased risk for cognitive impairment by 34% (=1.34,95%: 1.09-1.64), 40% (=1.40,95%: 1.17-1.69) and 43% (=1.43,95%: 1.19-1.70), respectively. Trend test showed that the risk of cognitive impairment increased with the extension of sleep duration (>6 h), and there was a dose-response relationship (<0.001). However, self-rated sleep quality was not associated with the risk for cognitive impairment in the elderly. The shorter and longer sleep duration were associated an increased risk of cognitive impairment in the elderly aged ≥65 years in China, suggesting that optimizing sleep duration might delay the occurrence of cognitive impairment.

摘要

为探讨睡眠时间对中国老年人认知功能障碍风险的影响。2005年从中国老年健康影响因素跟踪调查(CLHLS)中收集了9679名认知功能完好的老年人的基线数据,并随访至2018年。采用Cox比例风险模型分析不同睡眠时间与老年人认知功能障碍风险之间的关联。与每天睡眠6小时的老年人相比,睡眠时间少于5小时的老年人认知功能障碍风险增加30%(=1.30,95%置信区间:1.05 - 1.62),睡眠时间为7小时、8小时和超过9小时的老年人认知功能障碍风险分别增加34%(=1.34,95%置信区间:1.09 - 1.64)、40%(=1.40,95%置信区间:1.17 - 1.69)和43%(=1.43,95%置信区间:1.19 - 1.70)。趋势检验表明,认知功能障碍风险随着睡眠时间延长(>6小时)而增加,且存在剂量反应关系(<0.001)。然而,自评睡眠质量与老年人认知功能障碍风险无关。在中国≥65岁的老年人中,较短和较长的睡眠时间均与认知功能障碍风险增加相关,这表明优化睡眠时间可能会延缓认知功能障碍的发生。

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