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miR-1270 通过靶向 MMD2 抑制乳腺癌的恶性进展。

MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2.

机构信息

Department of Oncological Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Department of Pathology, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

出版信息

J Healthc Eng. 2022 Mar 19;2022:3677720. doi: 10.1155/2022/3677720. eCollection 2022.

DOI:10.1155/2022/3677720
PMID:35345650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8957424/
Abstract

We aimed to detect the clinical significance of microRNA-1270 (miR-1270) in breast cancer (BCa) development and its potential influence on malignant phenotypes of BCa cells. The miR-1270 level in paired BCa and paracancerous tissues was detected. The Kaplan-Meier method was used for the prognosis analysis of miR-1270 in BCa. The biofunctions of miR-1270 in apoptosis and proliferation of breast cancer cells were evaluated. Downstream target of miR-1270 was predicted and confirmed. The involvement of monocyte to macrophage differentiation associated 2 (MMD2) in BCa development was finally illustrated. miR-1270 was lowly expressed in BCa tissues. Lowly expressed miR-1270 was associated with tumor staging, larger tumor size, and also worse prognostic results in patients with BCa. miR-1270 overexpression suppressed proliferation and increased apoptotic rate of BCa cells. Further exploration showed that MMD2 might be the target of miR-1270. MMD2 was upregulated in BCa tissues and negatively correlated to miR-1270 level. Importantly, MMD2 significantly neutralized the above biofunctions of miR-1270 in malignant phenotypes of BCa. Lowly expressed miR-1270 is a hallmark of poor prognosis in patients with BCa. It inhibits proliferative ability and increases apoptosis in BCa by negatively regulating the MMD2 level.

摘要

我们旨在检测 microRNA-1270（miR-1270）在乳腺癌（BCa）发展中的临床意义及其对 BCa 细胞恶性表型的潜在影响。检测配对的 BCa 和癌旁组织中的 miR-1270 水平。Kaplan-Meier 法用于分析 miR-1270 在 BCa 中的预后。评估 miR-1270 对乳腺癌细胞凋亡和增殖的生物学功能。预测和验证 miR-1270 的下游靶标。最后阐明了单核细胞到巨噬细胞分化相关 2（MMD2）在 BCa 发展中的作用。miR-1270 在 BCa 组织中低表达。低表达的 miR-1270 与肿瘤分期、肿瘤体积较大以及 BCa 患者的预后不良相关。miR-1270 过表达抑制 BCa 细胞的增殖并增加其凋亡率。进一步的探索表明，MMD2 可能是 miR-1270 的靶标。MMD2 在 BCa 组织中上调，并与 miR-1270 水平呈负相关。重要的是，MMD2 显著中和了 miR-1270 在 BCa 恶性表型中的上述生物学功能。低表达的 miR-1270 是 BCa 患者预后不良的标志。它通过负调控 MMD2 水平抑制 BCa 的增殖能力并增加其凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/8957424/70761cc2fff1/JHE2022-3677720.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/8957424/5fbf70e12427/JHE2022-3677720.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/8957424/aa5f22e0770f/JHE2022-3677720.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/8957424/4df274a31c4c/JHE2022-3677720.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/8957424/70761cc2fff1/JHE2022-3677720.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/8957424/5fbf70e12427/JHE2022-3677720.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/8957424/aa5f22e0770f/JHE2022-3677720.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/8957424/4df274a31c4c/JHE2022-3677720.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/8957424/70761cc2fff1/JHE2022-3677720.004.jpg

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