Department of Pharmacology and Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
Antiinflamm Antiallergy Agents Med Chem. 2022;21(1):2-9. doi: 10.2174/1871523021666220328121721.
Diosgenin (DG), a well-known steroid saponin, has shown anti-inflammatory effects. This review was aimed to discuss all published literature concerning the anti-inflammatory effects of diosgenin. Based on the modulatory impact of DG on the NF-κB pathway, its supplementation is associated with downregulation of the NF-κB pathway and TGF-β, resulting in inhibition of inflammation. It appears that upstream modulators of NF-κB signaling pathways such as Tlrs and downstream mediators include iNOS and COX-2, leading to the inhibition of the inflammatory response and development of pathological conditions. Due to the low toxicity of the herbal compounds, the risk of the side effects of DG use for the management of inflammatory disorders such as asthma, rheumatism, rhinitis, and arthritis is lower than that of synthetic glucocorticoids. It has been shown that regulation of NF-κB and oxidative stress signaling pathways by DG is beneficial against cardiotoxicity induced by chemotherapeutic agents such as doxorubicin.
薯蓣皂苷元（DG）是一种众所周知的甾体皂苷，具有抗炎作用。本综述旨在讨论所有关于薯蓣皂苷元抗炎作用的已发表文献。基于 DG 对 NF-κB 途径的调节作用，其补充与 NF-κB 途径和 TGF-β的下调有关，从而抑制炎症。似乎 NF-κB 信号通路的上游调节剂，如 Tlrs 和下游介质，包括 iNOS 和 COX-2，导致炎症反应和病理状况的发展受到抑制。由于草药化合物的毒性低，DG 用于治疗哮喘、风湿、鼻炎和关节炎等炎症性疾病的副作用风险低于合成糖皮质激素。已经表明，DG 对 NF-κB 和氧化应激信号通路的调节有利于对抗阿霉素等化疗药物引起的心脏毒性。
