Department of Endocrinology and Metabolism, University of Health Sciences, Ankara Training and Research Hospital, 06230, Ankara, Turkey.
Department of Endocrinology and Metabolism, University of Health Sciences, Gulhane Training and Research Hospital, 06010, Ankara, Turkey.
Curr Aging Sci. 2022 Aug 4;15(3):242-251. doi: 10.2174/1874609815666220328123744.
Diet can affect the body's acid-base balance due to its content of acid or base precursors. There is conflicting evidence for the role of metabolic acidosis in the development of cardiometabolic disorders, hypertension (HT), and insulin resistance (IR).
We hypothesized that dietary acid load (DAL) is associated with adverse metabolic risk factors and aimed to investigate this in the elderly.
A total of 114 elderly participants were included in the study. The participants were divided into four groups, such as HT, diabetes (DM), both HT and DM, and healthy controls. Anthropometric, biochemical, and clinical findings were recorded. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) results were obtained for three days, 24-hour dietary records via a nutrient database program (BeBiS software program).
The groups were matched for age, gender, and BMI. There was a statistically significant difference between the groups regarding NEAP (p =0.01) and no significant difference for PRAL ( p = 0.086). The lowest NEAP and PRAL levels were seen in the control group while the highest in the HT group. Both NEAP and PRAL were correlated with waist circumference (r = 0,325, p = 0.001; r=0,231, p =0,016, respectively).
Our data confirmed that subjects with HT and DM had diets with greater acid-forming potential. High NEAP may be a risk factor for chronic metabolic diseases, particularly HT. PRAL could not be shown as a significantly different marker in all participants. Dietary content has a significant contribution to the reduction of cardiovascular risk factors, such as HT, DM, and obesity.
由于饮食中酸或碱前体的含量，饮食会影响身体的酸碱平衡。代谢性酸中毒在心血管代谢疾病、高血压（HT）和胰岛素抵抗（IR）的发展中的作用存在相互矛盾的证据。
我们假设饮食酸负荷（DAL）与不良代谢危险因素有关，并旨在对此在老年人中进行研究。
共有 114 名老年人参与了这项研究。将参与者分为 HT、糖尿病（DM）、HT 和 DM 并存以及健康对照组四组。记录了人体测量学、生化和临床发现。通过营养数据库程序（BeBiS 软件程序）获得了三天的潜在肾酸负荷（PRAL）和净内源性酸产生（NEAP）结果。
各组在年龄、性别和 BMI 方面相匹配。NEAP 组间存在统计学差异（p = 0.01），PRAL 组间无显著差异（p = 0.086）。NEAP 和 PRAL 的最低水平见于对照组，最高水平见于 HT 组。NEAP 和 PRAL 均与腰围相关（r = 0.325，p = 0.001；r = 0.231，p = 0.016）。
我们的数据证实，HT 和 DM 患者的饮食具有更大的产酸潜力。高 NEAP 可能是慢性代谢性疾病的危险因素，尤其是 HT。PRAL 不能作为所有参与者的显著不同标志物。饮食内容对降低心血管危险因素（如 HT、DM 和肥胖）有重要贡献。
