Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, NO. 95 Yong-An Road, Xi-Cheng, Beijing, 100050, People's Republic of China.
J Cardiothorac Surg. 2022 Mar 27;17(1):55. doi: 10.1186/s13019-022-01804-y.
The letter to the editor was written in response to "Plasma interleukin-6 is a potential predictive biomarker for postoperative delirium (POD) among acute type a aortic dissection patients treated with open surgical repair", which is recently published by Lv et al. (J Cardiothorac Surg 16(1):146, 2021). In this article, Lv et al. conclude that plasma IL-6 is a potential biomarker for prediction of POD. However, we note several issues in this study that would have made interpretation of their results questionable. Our main concerns include the use of a short POD assessment time, no providing the data of analgesics and sedatives used in the ICU, application of incorrect statistical methods when assessing predictive ability of plasma IL-6 for the development of POD, and incorrect interpretation for the area under the receiver operating characteristic curve. We believe that addressing these issues will improve the transparency of this study and help the interpretation of findings.
这封给编辑的信是对最近由吕等人发表在《胸心血管外科杂志》（J Cardiothorac Surg 16(1):146, 2021）上的“血浆白细胞介素 6 是急性 A 型主动脉夹层患者开放性手术修复术后谵妄（POD）的潜在预测生物标志物”一文的回应。在这篇文章中，吕等人得出结论，血浆 IL-6 是预测 POD 的潜在生物标志物。然而，我们注意到这项研究中有几个问题，这些问题会使对其结果的解释产生疑问。我们主要关注的问题包括：POD 评估时间短，未提供 ICU 中使用的镇痛药和镇静剂的数据，在评估血浆 IL-6 对 POD 发展的预测能力时应用了不正确的统计方法，以及对受试者工作特征曲线下面积的错误解释。我们认为，解决这些问题将提高这项研究的透明度，并有助于对研究结果的解释。
