基因型与台湾地区胃癌风险的关联。
Association of Genotypes With Risk of Gastric Cancer in Taiwan.
机构信息
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
出版信息
Anticancer Res. 2022 Apr;42(4):1749-1755. doi: 10.21873/anticanres.15651.
BACKGROUND/AIM: Matrix metalloproteinase-2 (MMP-2) plays a critical role in the regulation of the extracellular matrix; however, its genotypes have seldom been examined in gastric cancer (GC). This study aimed to investigate the contribution of MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) genotypes to GC risk in a cohort of Taiwanese individuals.
MATERIALS AND METHODS
This study included 121 GC cases and 363 age- and sex-matched controls. The genotypes of MMP-2 were determined by typical polymerase chain reaction-restriction fragment length polymorphism.
RESULTS
The genotypic and allelic frequency analysis showed that MMP-2 rs243865 variant genotypes decreased the risk of GC. Stratification analysis showed that MMP-2 rs243865 genotypes associate with smoking, alcohol drinking, and Helicobacter pylori infection status to confer personal susceptibility to GC. There is no such association for MMP-2 rs2285053 genotype with GC risk.
CONCLUSION
The MMP-2 rs243865 genotypes may serve as a novel predictive marker for GC personal susceptibility among Taiwanese.
背景/目的：基质金属蛋白酶-2（MMP-2）在细胞外基质的调节中起着关键作用；然而，其基因型在胃癌（GC）中很少被研究。本研究旨在调查 MMP-2 启动子-1306（rs243865）和-735（rs2285053）基因型对台湾个体 GC 风险的贡献。
材料和方法
本研究包括 121 例 GC 病例和 363 名年龄和性别匹配的对照。通过典型的聚合酶链反应-限制性片段长度多态性确定 MMP-2 的基因型。
结果
基因型和等位基因频率分析表明，MMP-2 rs243865 变异基因型降低了 GC 的风险。分层分析表明，MMP-2 rs243865 基因型与吸烟、饮酒和幽门螺杆菌感染状况相关，赋予个体对 GC 的易感性。MMP-2 rs2285053 基因型与 GC 风险无相关性。
结论
MMP-2 rs243865 基因型可能是台湾个体 GC 个体易感性的新型预测标志物。
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