Guillois B, Guedes Y, Le Guen E, Le Bot M A, Riche C, Alix D
Pathol Biol (Paris). 1986 May;34(5):346-8.
Maximal and minimal tobramycin concentrations were studied in 16 preterm and 4 fullterm neonates on the last day of a four-day course of tobramycin (infusion of 2 mg/kg twice a day). Maximal concentrations were under 6 mg/l in all patients and minimal concentrations were above 2 mg/l in one-third of the preterm babies. Next, tobramycin pharmacokinetic parameters were studied in 4 fullterm and 4 preterm neonates following a first infusion of 2 mg/kg. Half-life was 4 hours in term babies and 7.75 hours in preterm babies. Mean clearance was 0.118 l/h/kg and 0.06 l/h/kg in fullterm and preterm babies respectively (significant difference). Our results show that the 2 mg/kg dosage is too low and that, in preterm neonates, the 12-hour interval between infusions is too short.
在16名早产儿和4名足月儿接受为期四天的妥布霉素疗程（每天两次静脉输注2mg/kg）的最后一天，研究了妥布霉素的最大和最小浓度。所有患者的最大浓度均低于6mg/l，三分之一的早产儿最小浓度高于2mg/l。接下来，在4名足月儿和4名早产儿首次输注2mg/kg后研究了妥布霉素的药代动力学参数。足月儿的半衰期为4小时，早产儿为7.75小时。足月儿和早产儿的平均清除率分别为0.118l/h/kg和0.06l/h/kg（有显著差异）。我们的结果表明，2mg/kg的剂量过低，并且在早产儿中，输注间隔12小时太短。
