[新型大环内酯类药物RU 28965与红霉素对沙眼衣原体的体外活性比较]
[Comparative in vitro activity of a new macrolide RU 28965 and of erythromycin against Chlamydia trachomatis].
作者信息
Dutilh B, de Barbeyrac B, Lafferrière C, Bébéar C
出版信息
Pathol Biol (Paris). 1986 May;34(5):445-7.
Activity of a new macrolide, RU 28965, and erythromycin against 8 Chlamydia trachomatis strains isolated from the human genital tract was studied. Minimal inhibitory concentrations were determined using cycloheximide-treated McCoy cells. Giemsa and immunofluorescence staining with monoclonal antibodies were used to detect Chlamydial inclusions. Immunofluorescence proved more sensitive and easier to read. All the strains were highly susceptible to RU 28965 (MIC = 0.05 mg/l - 0.1 mg/l) and erythromycin (MIC = 0.02 mg/l - 0.2 mg/l).
研究了一种新型大环内酯类药物RU 28965和红霉素对从人类生殖道分离出的8株沙眼衣原体菌株的活性。使用经放线菌酮处理的McCoy细胞测定最低抑菌浓度。采用吉姆萨染色和单克隆抗体免疫荧光染色检测衣原体包涵体。免疫荧光检测更敏感且更易于判读。所有菌株对RU 28965（MIC = 0.05 mg/l - 0.1 mg/l）和红霉素（MIC = 0.02 mg/l - 0.2 mg/l）均高度敏感。
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