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BAX 和 BAK 动力学控制细胞凋亡过程中线粒体 DNA 的释放。

BAX and BAK dynamics control mitochondrial DNA release during apoptosis.

机构信息

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Sandra and Edward Meyer Cancer Center, New York, NY, USA.

出版信息

Cell Death Differ. 2022 Jun;29(6):1296-1298. doi: 10.1038/s41418-022-00985-2. Epub 2022 Mar 26.

DOI:10.1038/s41418-022-00985-2
PMID:35347233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9177580/
Abstract

BAX and BAK are generally considered as fully interchangeable for mitochondrial permeabilization and consequent apoptotic cell death. Garcia-Saez and colleagues have recently documented striking kinetic differences that influence BAX and BAK oligomerization at the mitochondrial surface. These data have important implications for inflammatory responses driven by mitochondrial DNA.

摘要

BAX 和 BAK 通常被认为可完全互换用于线粒体通透化和随后的细胞凋亡。Garcia-Saez 及其同事最近记录了显著的动力学差异，这些差异影响线粒体表面 BAX 和 BAK 的寡聚化。这些数据对线粒体 DNA 驱动的炎症反应具有重要意义。