Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, India.
Ophthalmic Biophysics (AMd), L V Prasad Eye Institute, Hyderabad, India.
Eye (Lond). 2023 Mar;37(4):714-719. doi: 10.1038/s41433-022-02025-2. Epub 2022 Mar 26.
To assess the prognostic value of T category of the 8 edition of American Joint Committee on Cancer (AJCC) classification in periocular sebaceous gland carcinoma (SGC).
Retrospective interventional case series of 119 cases.
Based on the T category of 8th edition of AJCC classification, 119 periocular SGCs were classified into T1 (n = 33, 28%), T2 (n = 37, 31%) T3 (n = 17, 14%) and T4 (n = 32, 27%). There were no statistically significant differences in the rate of tumour recurrence based on T category. The outcome measures that showed significant increase with increase in T category included regional lymph node metastasis (3% for T1, 3% for T2, 12% for T3, and 44% for T4; p < 0.0001), systemic metastasis (0% for T1, 0% for T2, 12% for T3, and 25% for T4; p = 0.002) and death due to metastasis (0% for T1, 0% for T2, 12% for T3, and 22% for T4; p = 0.005). The 5-year Kaplan-Meier estimate rate for regional lymph node metastasis, systemic metastasis and metastasis-related death were all higher for the T4 category tumours (42%, p = 0.005; 34%, p = 0.0002; and 43%, p = 0.0001 respectively) compared to T1 (9%, 0%, and 0%), T2 (5%, 0%, and 0%) and T3 (10%, 17 and 8%) tumours.
Primary tumour (T) category of the 8 edition AJCC classification predicts the prognosis of patients with periocular SGC. The rates of lymph node metastasis, systemic metastasis, and death is much higher in T4 tumours compared to T1, T2, and T3 tumours. There was no association between T category and tumour recurrence.
评估第 8 版美国癌症联合委员会（AJCC）分类中 T 分期在眼周皮肤腺癌（SGC）中的预后价值。
回顾性干预性病例系列研究，共纳入 119 例患者。
根据第 8 版 AJCC 分类的 T 分期，119 例眼周 SGC 分为 T1（n=33，28%）、T2（n=37，31%）、T3（n=17，14%）和 T4（n=32，27%）。根据 T 分期，肿瘤复发率无统计学差异。随着 T 分期的增加，以下指标的结果显著增加：区域淋巴结转移（T1 为 3%，T2 为 3%，T3 为 12%，T4 为 44%；p<0.0001）、全身转移（T1 为 0%，T2 为 0%，T3 为 12%，T4 为 25%；p=0.002）和因转移导致的死亡（T1 为 0%，T2 为 0%，T3 为 12%，T4 为 22%；p=0.005）。T4 类肿瘤的 5 年 Kaplan-Meier 估计区域淋巴结转移、全身转移和转移相关死亡率均高于 T1 类肿瘤（42%，p=0.005；34%，p=0.0002；和 43%，p=0.0001）、T2 类肿瘤（5%，0%和 0%）和 T3 类肿瘤（10%，17%和 8%）。
第 8 版 AJCC 分类中的原发肿瘤（T）分期预测了眼周 SGC 患者的预后。与 T1、T2 和 T3 肿瘤相比，T4 肿瘤的淋巴结转移、全身转移和死亡的发生率要高得多。T 分期与肿瘤复发之间没有关联。
