Sedallian A
Pathol Biol (Paris). 1986 Jun;34(5 Pt 2):645-7.
We studied the susceptibility of 282 obligate anaerobes to 8 antibiotics. The strains were isolated from clinical specimens taken during 1983 and 1984. Minimal inhibitory concentrations (MICs) were determined using a microplate method for 245 strains and agar dilution for 33 Bacteroides asaccharolyticus strains. Tested strains were as follows: 85 Bacteroides fragilis, 71 Clostridium, 19 Fusobacterium nucleatum, 35 Peptostreptococcus, 39 Bacteroides oralis and Bacteroides bivius and 33 Bacteroides asaccharolyticus. Tested antibiotics were: metronidazole, clindamycin, minocycline, cefoxitin, cefotaxime, moxalactam, keflin and carbenicillin. For Bacteroides fragilis, the three most active antibiotics were metronidazole (inhibition of all strains with 8 micrograms/ml), minocycline and clindamycin (inhibition of 95% of strains by MICs less than or equal to 0.5 microgram/ml). However, four strains were resistant to clindamycin (MICs greater than 8 micrograms/ml). The other anaerobic strains tested were susceptible. However, a few Bacteroides bivius strains were resistant to keflin (MIC greater than or equal to 64 micrograms/ml for 5% of strains).
我们研究了282株专性厌氧菌对8种抗生素的敏感性。这些菌株是从1983年和1984年采集的临床标本中分离出来的。采用微孔板法对245株菌株测定最低抑菌浓度（MIC），对33株解糖胨拟杆菌采用琼脂稀释法。受试菌株如下：85株脆弱拟杆菌、71株梭菌、19株具核梭杆菌、35株消化链球菌、39株口腔拟杆菌和双路拟杆菌以及33株解糖胨拟杆菌。受试抗生素有：甲硝唑、克林霉素、米诺环素、头孢西丁、头孢噻肟、莫西沙星、头孢氨苄和羧苄青霉素。对于脆弱拟杆菌，三种最有效的抗生素是甲硝唑（8微克/毫升抑制所有菌株）、米诺环素和克林霉素（MIC小于或等于0.5微克/毫升抑制95%的菌株）。然而，有4株菌株对克林霉素耐药（MIC大于8微克/毫升）。其他受试厌氧菌均敏感。不过，有几株双路拟杆菌对头孢氨苄耐药（5%的菌株MIC大于或等于64微克/毫升）。
