Nanyang Medical College, Henan Province, Nanyang, P. R. China.
Nanyang first people's Hospital, Henan Province, Nanyang, P. R. China.
Lett Appl Microbiol. 2022 Nov;75(5):1103-1110. doi: 10.1111/lam.13710. Epub 2022 Apr 13.
Anhedonia is the core symptom of depression, which largely reflects the therapeutic effect of depression. Hypericum perforatum is one of the most important antidepressant herb that has fewer side effects than traditional antidepressants. Considering the antibacterial effect of Hypericum perforatum, we verified whether this antidepressant activity was related to intestinal microbiomics. So we established anhedonia mouse model to explore the underlying treatment mechanism of hyperforin, the key antidepressant ingredient of Hypericum perforatum and to screen new psychobiotics based on hyperforin. It was found that hyperforin prevented anhedonia induced by chronic restraint stress in mice and altered the richness and evenness of bacteria populations compared with stressed mice. Metastat analysis showed that Akkermansia muciniphila and Muribaculum intestinale were the bacterial species obviously affected by hyperforin, and their abundance in hyperforin-treated group significantly increased. The results suggest that the effect of hyperforin on anhedonia may be partly assisted by Akkermansia muciniphila. These also indicate that Muribaculum intestinale may be another important intestinal bacteria involved in the pathogenesis of anhedonia symptom and depression.
快感缺失是抑郁症的核心症状，在很大程度上反映了抑郁症的治疗效果。贯叶金丝桃是最重要的抗抑郁草药之一，其副作用比传统抗抑郁药少。考虑到贯叶金丝桃的抗菌作用，我们验证了这种抗抑郁活性是否与肠道微生物组学有关。因此，我们建立了快感缺失小鼠模型，以探索贯叶金丝桃中关键抗抑郁成分金丝桃素的潜在治疗机制，并基于金丝桃素筛选新的益生菌。结果发现，金丝桃素可预防慢性束缚应激诱导的小鼠快感缺失，并改变了与应激小鼠相比的细菌种群丰富度和均匀度。代谢组学分析表明，阿克曼氏菌和穆里巴库姆肠杆菌是受金丝桃素明显影响的细菌种类，金丝桃素处理组中它们的丰度显著增加。这些结果表明，金丝桃素对快感缺失的作用可能部分是通过阿克曼氏菌辅助的。这些也表明，穆里巴库姆肠杆菌可能是另一种参与快感缺失症状和抑郁症发病机制的重要肠道细菌。
