Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo City, Japan.
Center for Birth Cohort Studies, University of Yamanashi, Chuo City, Japan.
J Diabetes Investig. 2022 Aug;13(8):1444-1447. doi: 10.1111/jdi.13796. Epub 2022 Apr 18.
Gestational diabetes mellitus (GDM) is one of the most common pregnancy-related complications; it is associated with adverse pregnancy outcomes and metabolic disorders in offspring, consistent with the concept of the developmental origins of health and disease. This cohort study of women without diabetes (n = 761), who were part of the Yamanashi Adjunct Study of the Japan Environment and Children's Study, aimed to explore the associations between maternal GDM and their offspring's level of high-sensitivity C-reactive protein (hsCRP), a biomarker of inflammatory and cardiovascular diseases. We analyzed the associations between GDM and the offspring's hsCRP levels using a multiple logistic regression model. A mother with GDM significantly increased the risk for high hsCRP level by 4.07-fold (≥2.0 mg/L) in the child. As such, maternal GDM was significantly associated with increased serum hsCRP levels in 8-year-old children.
妊娠期糖尿病（GDM）是最常见的妊娠相关并发症之一；它与不良的妊娠结局和后代的代谢紊乱有关，与健康和疾病的发育起源概念一致。这项针对无糖尿病女性（n=761）的队列研究是日本环境与儿童研究的山梨县附加研究的一部分，旨在探讨母体 GDM 与其后代高敏 C 反应蛋白（hsCRP）水平之间的关系，hsCRP 是炎症和心血管疾病的生物标志物。我们使用多因素逻辑回归模型分析了 GDM 与后代 hsCRP 水平之间的关系。患有 GDM 的母亲使孩子发生 hsCRP 水平升高（≥2.0mg/L）的风险显著增加 4.07 倍。因此，母体 GDM 与 8 岁儿童血清 hsCRP 水平升高显著相关。
