Montolío-Marzo Santiago, Gallego-Pinazo Roberto, Dolz-Marco Rosa, Lanzagorta-Aresti Aitor, Pérez-López Marta
FISABIO Oftalmología Médica, Valencia, Spain.
Oftalvist, Valencia, Spain.
Eur J Ophthalmol. 2023 Jul;33(4):NP119-NP124. doi: 10.1177/11206721221090033. Epub 2022 Mar 29.
Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of optic nerve swelling and optic neuropathy in adults over 50 years of age. It has been rarely reported during pregnancy, mostly related to systemic and ocular predisposing conditions.
We report the case of a 44 years-old healthy female with no previous remarkable clinical history. She had in vitro fertilisation treatment to get pregnant. 18 days after uneventful cesarean section she referred sudden painless vision loss in her right eye (RE), denser inferiorly, with concurrent optic disc edema and relative afferent pupillary defect. Steroid intravenous treatment during the acute episode showed no improvement. Our patient showed normal magnetic resonance imaging (MRI), blood test, autoimmune disease biomarkers, infectious serology and inflammatory markers. She was diagnosed of RE NAION. After one year follow-up visual field defect remains stable.
As far as we know this is the first report of NAION after in vitro fertilisation, uneventful pregnancy and cesarean section showing no systemic or ocular risk factors other than a small cup to disc ratio. Hemodynamic and hormonal changes during late pregnancy and uneventful cesarean section can trigger an episode of NAION in a healthy young woman.
非动脉炎性前部缺血性视神经病变(NAION)是50岁以上成年人视神经肿胀和视神经病变的最常见原因。孕期很少有相关报道,大多与全身和眼部的易感因素有关。
我们报告一例44岁健康女性病例,既往无显著临床病史。她通过体外受精治疗成功怀孕。在剖宫产手术顺利进行18天后,她出现右眼突发无痛性视力丧失,下方更明显,并伴有视盘水肿和相对传入性瞳孔障碍。急性发作期静脉注射类固醇治疗无效。我们的患者磁共振成像(MRI)、血液检查、自身免疫性疾病生物标志物、感染血清学和炎症标志物均正常。她被诊断为右眼NAION。经过一年的随访,视野缺损保持稳定。
据我们所知,这是首例体外受精、孕期顺利及剖宫产术后发生NAION的病例报告,除杯盘比小外无其他全身或眼部危险因素。妊娠晚期和剖宫产手术顺利过程中的血流动力学和激素变化可引发健康年轻女性发生NAION。