College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, P. R. China.
Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, P.R. China.
Food Funct. 2022 Apr 20;13(8):4527-4536. doi: 10.1039/d1fo03054j.
Lycopene (LYC), as a kind of carotene, has antioxidant effects. Di(2-ethylhexyl) phthalate (DEHP) was used to improve the flexibility of plastics. However, the potential role of LYC in DEHP induced cardiac injury in mice remains unclear. Therefore, the aim of this study was to investigate the role and mechanism of LYC in DEHP induced cardiac injury. Male ICR mice were treated with DEHP (500 or 1000 mg per kg BW per day) and/or LYC (5 mg per kg BW per day) for 28 days. The results of histopathology and ultrastructure showed that LYC relieved the decrease of mitochondrial volume density and myocardial fibre disorder induced by DEHP. Subsequently, LYC attenuated DEHP-induced mitochondrial damage, mitochondrial unfolded protein response (UPR) activation, nuclear factor erythroid 2-related factor 2 (Nrf2) mediated oxidative stress and heat shock response (HSR) activation induced by DEHP. LYC regulates UPR to prevent DEHP-induced cardiac mitochondrial damage. Thus, this study provided new evidence of UPR as a target for LYC treatment preventing DEHP-induced cardiac disease.
番茄红素（LYC）作为一种类胡萝卜素，具有抗氧化作用。邻苯二甲酸二（2-乙基己基）酯（DEHP）用于提高塑料的柔韧性。然而，LYC 在 DEHP 诱导的小鼠心脏损伤中的潜在作用尚不清楚。因此，本研究旨在探讨 LYC 在 DEHP 诱导的心脏损伤中的作用和机制。雄性 ICR 小鼠用 DEHP（500 或 1000mg/kgBW/天）和/或 LYC（5mg/kgBW/天）处理 28 天。组织病理学和超微结构结果表明，LYC 缓解了 DEHP 引起的线粒体体积密度降低和心肌纤维紊乱。随后，LYC 减弱了 DEHP 诱导的线粒体损伤、线粒体未折叠蛋白反应（UPR）激活、核因子红细胞 2 相关因子 2（Nrf2）介导的氧化应激和热休克反应（HSR）激活。LYC 通过调节 UPR 来防止 DEHP 诱导的心脏线粒体损伤。因此，本研究为 UPR 作为 LYC 治疗预防 DEHP 诱导的心脏疾病的靶点提供了新的证据。
