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具有优异机械性能和在各种溶液中高稳定性的硬而强的水凝胶管。

Stiff and strong hydrogel tube with great mechanical properties and high stability in various solutions.

机构信息

CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui 230026, China.

School of Material Science and Engineering, Anhui University, Hefei, Anhui 230601, China.

出版信息

J Mater Chem B. 2022 Apr 20;10(16):3126-3137. doi: 10.1039/d2tb00124a.

Abstract

Hydrogel tubes are widely used in fields such as artificial blood vessels, drug delivery, biomedical scaffolds and cell adhesion, yet their application is often limited by unsatisfactory mechanical properties and poor stability in various solutions. Herein, a novel hydrogel tube exhibiting a remarkable mechanical performance and stability in various solutions is prepared by introducing a dual physically cross-linked double network (DN) hydrogel matrix. The obtained hydrogel tube can withstand ∼60 N load without fracture and be stretched to over twice its original length before and after immersing in various solutions. The great mechanical properties and stability in various solutions of hydrogel tubes are due to the introduction of a dual physically cross-linked poly(acrylamide--acrylic acid)/carboxymethylcellulose sodium/Fe DN hydrogel, which possesses high elastic modulus (3.71 MPa), fracture energy (15.4 kJ m), and great stability in various solutions. In addition, the hydrogel tubes with different thickness, diameters, shapes and the multiple branched hydrogel tubes can also be fabricated to enable further functionalization for application requirements. Therefore, this new type of hydrogel tube presents tremendous potential for applications in biomedical and engineering fields.

摘要

水凝胶管广泛应用于人工血管、药物输送、生物医学支架和细胞黏附等领域,但由于其机械性能不理想和在各种溶液中的稳定性差,其应用往往受到限制。在此,通过引入双物理交联的双重网络(DN)水凝胶基质,制备了一种在各种溶液中具有显著机械性能和稳定性的新型水凝胶管。所得到的水凝胶管在不破裂的情况下可以承受约 60 N 的负载,并且在浸入各种溶液前后可以拉伸到原始长度的两倍以上。水凝胶管在各种溶液中具有优异的机械性能和稳定性,这归因于引入了双物理交联的聚(丙烯酰胺-丙烯酸)/羧甲基纤维素钠/Fe DN 水凝胶,其具有高弹性模量(3.71 MPa)、断裂能(15.4 kJ m)和在各种溶液中的优异稳定性。此外,还可以制备具有不同厚度、直径、形状和多个分支的水凝胶管,以满足应用要求进行进一步功能化。因此,这种新型水凝胶管在生物医学和工程领域具有巨大的应用潜力。

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