调节信号：ATP敏感性钾通道引导血流至脑毛细血管。
Tuning the signal: ATP-sensitive K channels direct blood flow to cerebral capillaries.
作者信息
Jackson William F
机构信息
Department of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA. Email:
出版信息
Sci Signal. 2022 Mar 29;15(727):eabo1118. doi: 10.1126/scisignal.abo1118.
PMID:35349301
Abstract
Cerebral blood flow must be exquisitely regulated to match the metabolic demands of neurons. In this issue of , Sancho characterize functional ATP-sensitive K (K) channels in cerebral capillary endothelial cells and pericytes that can be activated by adenosine signaling, thereby leading to increases in capillary blood flow.
摘要
脑血流量必须得到精确调节，以匹配神经元的代谢需求。在本期杂志中，桑乔等人描述了脑毛细血管内皮细胞和周细胞中可被腺苷信号激活的功能性ATP敏感性钾（K）通道，从而导致毛细血管血流量增加。
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