RUMA 和 RUPCR 在儿童过敏性紫癜中的应用。
RUMA and RUPCR in children with Henoch-Schonlein purpura.
机构信息
Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Clinical Laboratory, Zhejiang Hospital, Hangzhou, China.
出版信息
J Clin Lab Anal. 2022 May;36(5):e24376. doi: 10.1002/jcla.24376. Epub 2022 Mar 29.
OBJECTIVE
The aim of this study was to compare the qualitative and quantitative targets in the detection of proteinuria in children with HSP.
METHODS
Three hundred and forty children were taken as the research subjects. Qualitative and a series of quantitative indicators of urine protein were tested.
RESULTS
The qualitative and quantitative of protein in 340 children were analyzed retrospectively. Correlation analysis found that 24hUTP had a strong correlation with age, RUMA, RUPCR, and qualitative urine occult blood (p < 0.01, for all). After regression analysis, RUMA and RUPCR were still significantly correlated with 24hUTP (p < 0.01). At the same time, RUMA and RUPCR had good diagnostic accuracy for proteinuria. When the RUPCR ratio was set as 0.415, the diagnostic sensitivity was 83%, and the specificity was 98.7%. When RUMA was set as 68.215, the sensitivity was 94.3% and the specificity was 96.2%.
CONCLUSION
Compared with 24hUTP, RUMA and RUPCR had high sensitivity and specificity for monitoring proteinuria in children with HSP.
目的
本研究旨在比较 HSP 患儿蛋白尿检测的定性和定量指标。
方法
选取 340 例患儿作为研究对象，对其尿液蛋白进行定性和一系列定量指标检测。
结果
回顾性分析 340 例患儿的尿蛋白定性和定量结果。相关性分析发现，24hUTP 与年龄、RUMA、RUPCR 和定性尿潜血均具有较强相关性（p<0.01，均）。经回归分析，RUMA 和 RUPCR 与 24hUTP 仍具有显著相关性（p<0.01）。同时，RUMA 和 RUPCR 对蛋白尿具有良好的诊断准确性。当 RUPCR 比值设定为 0.415 时，诊断灵敏度为 83%，特异性为 98.7%；当 RUMA 设定为 68.215 时，灵敏度为 94.3%，特异性为 96.2%。
结论
与 24hUTP 相比，RUMA 和 RUPCR 对 HSP 患儿蛋白尿的监测具有较高的灵敏度和特异性。
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