Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, USA.
Epilepsy Res. 2022 May;182:106908. doi: 10.1016/j.eplepsyres.2022.106908. Epub 2022 Mar 15.
To investigate structural connectivity after total callosotomy.
Deterministic fiber tracking (tractography) of whole brain white matter was performed on 13 epilepsy patients pre- and post-callosotomy. The analysis of structural connectivity was based on graph theory and network-based analysis with a focus on the inter- and intrahemispheric networks. Clinical demographic data including seizure patterns and outcomes were scored for the identification of correlations.
After total callosotomy, structural interhemispheric networks were significantly interrupted. Specific changes were observed in the structural intrahemispheric networks in both hemispheres: 3 edges presented with significant decreases in the left hemisphere, whereas 2 edges presented with significant decreases in the right hemisphere. No global changes were observed in the network density, average weighted strength, average characteristic path length, or global efficiency of intrahemispheric networks. The intrahemispheric hubs and nodal efficiency were minimal changed after callosotomy.
While there was a significant decrease in structural interhemispheric connectivity post-callosotomy, we observed synchronously decremented changes of intrahemispheric edges in each hemisphere. This study suggests that white matter maintains the structural connectivity intrahemispherically although functional connectivity recovered after total callosotomy.
研究全胼胝体切开术后的结构连接。
对 13 例癫痫患者在胼胝体切开术前和术后进行全脑白质的确定性纤维追踪（轨迹）。结构连接的分析基于图论和基于网络的分析，重点是半球间和半球内网络。对临床人口统计学数据（包括发作模式和结果）进行评分，以确定相关性。
全胼胝体切开术后，结构的半球间网络显著中断。在两个半球的结构半球内网络中观察到特定的变化：3 个边缘在左半球表现出显著减少，而 2 个边缘在右半球表现出显著减少。半球内网络的网络密度、平均加权强度、平均特征路径长度或全局效率没有观察到全局变化。胼胝体切开术后，半球内枢纽和节点效率的变化最小。
虽然胼胝体切开术后半球间结构连接有显著下降，但我们观察到每个半球内半球间边缘的同步下降变化。这项研究表明，尽管在全胼胝体切开术后功能连接得到恢复，但白质在半球内仍保持结构连接。
