Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science of Engineering, National Yang-Ming University, Taipei, Taiwan.
Epilepsia. 2019 Jun;60(6):1126-1136. doi: 10.1111/epi.14933. Epub 2019 May 14.
To investigate whether interhemispheric functional connectivity (FC) recovers in the first year after total callosotomy.
Eight epilepsy patients undergoing total callosotomy were recruited. Resting-state functional magnetic resonance imaging was acquired before and after surgery. The precallosotomy and postcallosotomy interhemispheric and intrahemispheric FC was analyzed by using graph theory and voxel-mirrored homotopic connectivity (VMHC). The seizure outcome was scored using the Engel surgical outcome scale.
After callosotomy (mean postoperative interval = 4 months), the network density, average node degree, characteristic path length, and global efficiency of the whole interhemispheric networks were significantly decreased, compared to those in the precallosotomy networks. However, postcallosotomy interhemispheric FC and homotopic VMHC were not significantly reduced in bilateral frontal and temporal lobes. The network density and average node degree of the intrahemispheric networks were significantly increased. The characteristic path length and global efficiency of intrahemispheric networks were unchanged.
The interhemispheric FC may be preserved or recover early within the first postoperative year after total callosotomy, particularly in the frontal and anterior temporal lobes.
探讨全胼胝体切开术后 1 年内是否能恢复大脑两半球间的功能连接。
招募了 8 名接受全胼胝体切开术的癫痫患者。在手术前后采集静息态功能磁共振成像数据。使用图论和镜像同伦相关（VMHC）分析术前和术后大脑两半球间及半球内的功能连接。采用 Engel 手术结果量表对癫痫发作结果进行评分。
与术前网络相比，术后（平均术后间隔=4 个月）整个大脑两半球网络的网络密度、平均节点度、特征路径长度和全局效率显著降低。然而，双侧额颞叶的术后大脑两半球间功能连接和同伦 VMHC 没有明显减少。半球内网络的网络密度和平均节点度显著增加。半球内网络的特征路径长度和全局效率保持不变。
全胼胝体切开术后 1 年内，大脑两半球间的功能连接可能得到保留或早期恢复，特别是在前额和前颞叶。
