Bures J, Horák V, Buresová E, Fixa B, Komárková O, Hartmann M
Scand J Gastroenterol. 1986 Sep;21(7):819-23. doi: 10.3109/00365528609011124.
There are several indirect arguments for a possible role of colicins in chronic inflammatory bowel disease (IBD). Colicinogeny was therefore investigated in 54 patients with ulcerative colitis, 39 patients with Crohn's disease, and 160 clinically healthy controls. No significant difference was found among the examined groups. The leukocyte migration inhibition test (with colicins as antigens) was performed to estimate cellular hypersensitivity to colicins. Migration indices not exceeding the normal range in controls contrasted with abnormal values found in 36% of ulcerative colitis and 80% of Crohn's disease patients. The results are believed to be proof of cellular hypersensitivity of IBD patients to colicins of their own Escherichia coli strains. The importance of this finding must be further clarified.
关于大肠杆菌素在慢性炎症性肠病（IBD）中可能发挥的作用，有几个间接证据。因此，对54例溃疡性结肠炎患者、39例克罗恩病患者和160名临床健康对照者进行了大肠杆菌素生成情况的调查。在各检查组之间未发现显著差异。进行了白细胞迁移抑制试验（以大肠杆菌素作为抗原）来评估细胞对大肠杆菌素的超敏反应。对照组中迁移指数未超过正常范围，而溃疡性结肠炎患者中有36%、克罗恩病患者中有80%出现了异常值。这些结果被认为是IBD患者对自身大肠杆菌菌株的大肠杆菌素存在细胞超敏反应的证据。这一发现的重要性必须进一步阐明。
