Genetic Analysis of a Family with Multiple Incidences of Prostate Cancer.

A family with multiple members diagnosed with prostate cancer was identified, and genetic variants were analyzed. Three brothers were diagnosed with prostate cancer. Germline variants in , , , and were found through next-generation DNA sequencing using a hereditary cancer panel. The G275D variant was present in patients, but absent in the healthy member. An variant was found in 1 patient. Several mutations were predicted to be deleterious by a set of computation programs. Multiple gene mutations might contribute to the overall predisposition to prostate cancer in the family. Even in cases with potentially deleterious variants in or , there could be diverse clinical manifestations.