Department of Pediatric Hematology and Oncology, Shenzhen Children's Hospital, China Medical University, Shenzhen, Guangdong 518000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Mar 15;24(3):339-344. doi: 10.7499/j.issn.1008-8830.2112120.
Neuroblastoma (NB) is the most common extracranial solid tumor in children and has the features of high recurrence rate and low survival rate, and therefore, early diagnosis, treatment response evaluation, and recurrence monitoring are of great significance for NB patients. Liquid biopsy refers to the detection of cells and nucleic acids in fluid specimens, mainly blood. It is noninvasive and can overcome tumor heterogeneity, thus making it possible to achieve the early diagnosis and dynamic detection of NB. This review introduces the latest advances in clinical research on the application of liquid biopsy in NB.
神经母细胞瘤（NB）是儿童最常见的颅外实体瘤，具有高复发率和低生存率的特点，因此，早期诊断、治疗反应评估和复发监测对 NB 患者具有重要意义。液体活检是指对液体标本（主要是血液）中的细胞和核酸进行检测。它具有非侵入性，可以克服肿瘤异质性，从而实现 NB 的早期诊断和动态检测。本文综述了液体活检在 NB 临床研究中的最新进展。
