对维生素A缺乏相关夜盲症治疗反应的系列视网膜电图监测
Serial ERG monitoring of response to therapy in vitamin A deficiency related night blindness.
作者信息
Poornachandra B, Jayadev Chaitra, Sharief Shama, Shetty Rohit
机构信息
Vitreoretina Services, Narayana Nethralaya Eye Institute, Bangalore, India.
Vitreoretina Services, Narayana Nethralaya Eye Institute, Bangalore, India
出版信息
BMJ Case Rep. 2022 Mar 29;15(3):e247856. doi: 10.1136/bcr-2021-247856.
Two male patients with known systemic disorders who presented with complaints of nyctalopia underwent a complete ophthalmic examination including electrophysiological evaluation and serum vitamin A (retinol) levels. A significant vitamin A deficiency was detected, supplementation started and repeat electroretinogram (ERG) testing was carried out to monitor the timeline of recovery. Restoration of rod and generalised cone function was rapid within the first week of receiving treatment and near normal recovery was seen after 1 month of supplementation. Serial monitoring of ERG changes in vitamin A deficiency (VAD) associated night blindness plays an important role to demonstrate functional recovery post-treatment. The different effects of VAD on rod and cone function, and their rate of recovery, may reflect differences in the visual cycle between the two photoreceptors. We report the serial ERG changes in VAD related night blindness secondary to intestinal lipofuscinosis and liver cirrhosis in two patients.
两名患有已知全身性疾病且主诉夜盲的男性患者接受了包括电生理评估和血清维生素A（视黄醇）水平检测在内的全面眼科检查。检测到显著的维生素A缺乏，开始补充维生素A，并进行重复视网膜电图（ERG）测试以监测恢复进程。在接受治疗的第一周内，视杆细胞和普遍的视锥细胞功能迅速恢复，补充维生素A 1个月后可见接近正常的恢复情况。对维生素A缺乏（VAD）相关夜盲患者的ERG变化进行连续监测，对于证明治疗后的功能恢复具有重要作用。VAD对视杆细胞和视锥细胞功能的不同影响及其恢复速度，可能反映了这两种光感受器视觉循环的差异。我们报告了两名因肠道脂褐质沉积症和肝硬化继发的VAD相关夜盲患者的ERG连续变化情况。
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