肾移植患者膀胱小细胞癌与 BK 病毒相关。
BK virus associated with small cell carcinoma of bladder in a patient with renal transplant.
机构信息
Department of Internal Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
Division of Infectious Diseases, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
出版信息
BMJ Case Rep. 2022 Mar 29;15(3):e244740. doi: 10.1136/bcr-2021-244740.
A man in his 70s with a complex medical history, including cadaveric renal transplant, presented with recurrent urinary tract infections. Investigation revealed recurrent urinary pathogens, including and persistent BK viruria. Cystoscopy revealed a pedunculated mass in the right posterior-lateral wall, inferior to the transplant urethral orifice, and biopsy of this mass showed invasive small cell carcinoma with a prominent adenocarcinoma component. The tumour was treated with complete transurethral resection followed by carboplatin, etoposide and radiation. Laboratory analysis of biopsied samples showed immunostaining and molecular evidence of BK virus DNA in the cancer cells. Follow-up cystoscopies have shown no recurrence of the cancer.
一位 70 多岁的男性，有复杂的病史，包括尸体肾移植，反复出现尿路感染。检查发现反复出现的尿路病原体，包括 和持续的 BK 病毒尿。膀胱镜检查显示右后外侧壁有一个带蒂的肿块，位于移植尿道口下方，该肿块的活检显示为浸润性小细胞癌，并有明显的腺癌成分。该肿瘤采用完全经尿道切除，随后采用卡铂、依托泊苷和放疗进行治疗。活检样本的实验室分析显示，癌细胞中存在 BK 病毒 DNA 的免疫染色和分子证据。后续的膀胱镜检查显示癌症没有复发。
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