Department of Physiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
Department of Internal Medicine, School of Medicine, College of Health Sciences Unit Makerere University, Kampala, Uganda.
Sci Rep. 2022 Mar 28;12(1):5296. doi: 10.1038/s41598-022-09375-7.
An estimated one billion people globally live with hypovitaminosis D. Studies have indicated that vitamin D deficiency is a risk factor for active tuberculosis (TB) disease. The aim of this study was to determine the association between vitamin D deficiency and TB status among patients with active TB, latent TB infection (LTBI) and those without TB infection. In a cross-sectional study of active TB patients, LTBI, QuantiFERON GOLD testpositive and (QFNTST) household contact and controls QuantiFERON GOLD testnegative (QFNTST) samples vitamin D levels were compared. Vitamin D status was determined by measurement of total vitamin D levels with 56 samples of active TB patients, 17 with LTBI, and 22 without TB infection using electrochemiluminescence. The median interquartile range (IQR) age of the study participants was 28 (20-35) years, and the majority (63%) were females. The median (IQR) vitamin D levels were 18 ng/ml (14-24). All groups had vitamin D hypovitaminosis with significantly lower levels among active TB patients (17 ng/ml, 13, 2) than among LTBI individuals (23 ng/ml 16-29) and those without TB infection (22 ng/ml, 17-28).
全球估计有 10 亿人患有维生素 D 缺乏症。研究表明，维生素 D 缺乏是活动性结核病（TB）发病的一个危险因素。本研究旨在确定维生素 D 缺乏与活动性 TB、潜伏性 TB 感染（LTBI）和无 TB 感染患者之间的关系。在一项活动性 TB 患者、LTBI、QuantiFERON GOLD testpositive（QFNTST）家庭接触者和对照 QuantiFERON GOLD testnegative（QFNTST）样本的横断面研究中，比较了维生素 D 水平。通过电化学发光法测量 56 例活动性 TB 患者、17 例 LTBI 患者和 22 例无 TB 感染患者的总维生素 D 水平来确定维生素 D 状态。研究参与者的中位（IQR）年龄为 28（20-35）岁，大多数（63%）为女性。中位（IQR）维生素 D 水平为 18ng/ml（14-24）。所有组均存在维生素 D 缺乏症，活动性 TB 患者的维生素 D 水平明显低于 LTBI 患者（17ng/ml，13，2）和无 TB 感染患者（22ng/ml，17-28）。
