Department of Chemistry, Fudan University, Shanghai 200433, China.
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Org Biomol Chem. 2022 Apr 13;20(15):3072-3075. doi: 10.1039/d2ob00296e.
The base-controlled dearomative [3 + 2] cycloaddition reaction between 3-nitroindoles and fumaric acid amide esters has been disclosed by using the dearomatization and aromatization strategy. Three kinds of diverse functionalized pyrrolo[2,3-]indole derivatives were obtained respectively with excellent chemoselectivities and good diastereoselectivities using different bases.
本文报道了一种通过去芳构化和芳构化策略实现的 3-硝基吲哚与富马酸酰胺酯的基底控制的去芳构[3+2]环加成反应。使用不同的碱，分别以优异的化学选择性和良好的非对映选择性得到了三种不同功能化的吡咯并[2,3-]吲哚衍生物。
