自闭症谱系障碍儿童胼胝体体积：与性别相关的差异。
Corpus Callosum Volumes in Children with Autism Spectrum Disorders: Sex-Associated Differences.
机构信息
National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Chongqing Engineering Research Center for Clinical Big-Data and Drug Evaluation, Medical Data Science, Academy of Chongqing Medical University, Chongqing, 400014, China.
出版信息
J Autism Dev Disord. 2023 Jun;53(6):2421-2429. doi: 10.1007/s10803-022-05538-7. Epub 2022 Mar 29.
This study aimed to analyze the relationship between sex and corpus callosum (CC) volume in children with autism spectrum disorders (ASD) aged 2-4 years. This prospective study included 50 children with ASD and 50 typically developing (TD) children aged 2-4 years. Midsagittal slices of the CCs of the participants were divided into five subregions using FreeSurfer software. The PMCC, AMCC and TCC volumes were significantly higher in ASD participants than in TD participants, and results were significant in females with ASD rather than in males with ASD (all P < 0.05). In toddlers with ASD, the CC volumes were increased and more pronounced in females than in males. This could be due to overgrowth of axons or/and axonal pruning disorders.
本研究旨在分析 2-4 岁自闭症谱系障碍（ASD）儿童的性别与胼胝体（CC）体积之间的关系。这项前瞻性研究纳入了 50 名 2-4 岁的 ASD 儿童和 50 名典型发育（TD）儿童。使用 FreeSurfer 软件将参与者的 CC 的中矢状切片分为五个亚区。ASD 组参与者的 PMCC、AMCC 和 TCC 体积明显高于 TD 组，且 ASD 女性组的结果明显高于 ASD 男性组（均 P<0.05）。在 ASD 幼儿中，CC 体积在女性中增加得更明显，且比男性更明显。这可能是由于轴突过度生长或/和轴突修剪障碍。
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