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修订型吸收不良性减重手术的长期结果:获益是否大于风险?

Long-Term Outcomes of Revisional Malabsorptive Bariatric Surgery: Do the Benefits Outweigh the Risk?

机构信息

Department of Surgery, Central Clinical School, Monash University, Level 6, Alfred Centre, 99 Commercial Road, 3002 VIC, Melbourne, Australia.

Oesophago-Gastric and Bariatric Surgical Unit, Department of General Surgery, The Alfred Hospital, Melbourne, 3004, Australia.

出版信息

Obes Surg. 2022 Jun;32(6):1822-1830. doi: 10.1007/s11695-022-06019-7. Epub 2022 Mar 30.

Abstract

PURPOSE

To evaluate the long-term outcomes of revisional malabsorptive bariatric surgery.

MATERIALS AND METHODS

Malabsorptive bariatric procedures are increasingly performed in the revisional setting. We collated and analysed prospectively recorded data for all patients who underwent a revisional Biliopancreatic diversion + / - duodenal switch (BPD + / - DS) over a 17-year period.

RESULTS

We identified 102 patients who underwent a revisional BPD + / - DS. Median follow-up was 7 years (range 1-17). There were 21 (20.6%) patients permanently lost to follow-up at a median of 5 years postoperatively. Mean total weight loss since the revisional procedure of 22.7% (SD 13.4), 20.1% (SD 10.5) and 17.6% (SD 5.5) was recorded at 5, 10 and 15 years respectively. At the time of revisional surgery, 23 (22.5%) patients had diabetes and 16 (15.7%) had hypercholesterolaemia with remission of these occurring in 20 (87%) and 7 (44%) patients respectively. Nutritional deficiencies occurred in 82 (80.4%) patients, with 10 (9.8%) patients having severe deficiencies requiring periods of parenteral nutrition. Seven (6.9%) patients required limb lengthening or reversal procedures. There were 16 (15.7%) patients who experienced a complication within 30 days, including 3 (2.9%) anastomotic leaks. Surgery was required in 42 (41.2%) patients for late complications.

CONCLUSION

Revisional malabsorptive bariatric surgery induces significant long-term weight loss and comorbidity resolution. High rates of temporary and permanent attrition from follow-up are of major concern, given the high prevalence of nutritional deficiencies. These data question the long-term safety of malabsorptive bariatric procedures due to the inability to ensure compliance with nutritional supplementation and long-term follow-up requirements.

KEY POINTS

• Revisional bariatric surgery workload is increasing • Revisional malabsorptive surgery is efficacious for weight loss and comorbidity resolution • Revisional malabsorptive surgery is associated with high rates of nutritional deficiencies • Attrition from follow-up in this specific cohort of patients is of particular concern due to the risk of undiagnosed and untreated nutritional deficiencies.

摘要

目的

评估可复发性吸收不良性减重手术的长期效果。

材料与方法

吸收不良性减重手术在可复发性减重手术中越来越常见。我们收集并分析了 17 年来所有接受可复发性胆胰分流术+/-十二指肠转位术(BPD+/-DS)的患者的前瞻性记录数据。

结果

我们共纳入 102 例接受可复发性 BPD+/-DS 的患者。中位随访时间为 7 年(1-17 年)。21 例(20.6%)患者在术后 5 年时永久性失访。自可复发性手术以来,体重减轻的平均值为 22.7%(SD 13.4)、20.1%(SD 10.5)和 17.6%(SD 5.5),分别记录于术后 5、10 和 15 年。在进行可复发性手术时,23 例(22.5%)患者患有糖尿病,16 例(15.7%)患有高胆固醇血症,其中 20 例(87%)和 7 例(44%)患者的病情得到缓解。82 例(80.4%)患者出现营养缺乏,10 例(9.8%)患者出现严重缺乏,需要接受一段时间的肠外营养。7 例(6.9%)患者需要进行肢体延长或反转手术。16 例(15.7%)患者在 30 天内出现并发症,包括 3 例(2.9%)吻合口漏。42 例(41.2%)患者因迟发性并发症需要手术治疗。

结论

可复发性吸收不良性减重手术可显著减轻体重并解决合并症。临时和永久性随访流失率较高,令人严重关切,考虑到营养缺乏症的高患病率。这些数据由于无法确保遵守营养补充和长期随访要求,对吸收不良性减重手术的长期安全性提出质疑。

关键点

  1. 可复发性减重手术工作量不断增加。

  2. 可复发性吸收不良性手术对减轻体重和解决合并症有效。

  3. 可复发性吸收不良性手术与高营养缺乏率相关。

  4. 由于存在未确诊和未治疗的营养缺乏症风险,因此该特定患者队列中失访的情况尤其令人担忧。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec4/9072481/8458b3e9377d/11695_2022_6019_Fig1_HTML.jpg

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