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胆胰转流术后因副作用过多或减重效果不佳而进行的修正和逆转:关于适应证和手术方法的当前文献综述

Revision and reversal after biliopancreatic diversion for excessive side effects or ineffective weight loss: a review of the current literature on indications and procedures.

作者信息

Topart Philippe A, Becouarn Guillaume

机构信息

Clinique de l׳Anjou, Société de Chirurgie Viscérale, Angers, France.

Clinique de l׳Anjou, Société de Chirurgie Viscérale, Angers, France.

出版信息

Surg Obes Relat Dis. 2015 Jul-Aug;11(4):965-72. doi: 10.1016/j.soard.2015.01.015. Epub 2015 Jan 28.

Abstract

BACKGROUND

Biliopancreatic diversion is a powerful bariatric procedure that relies on gastric restriction combined with a large malabsorptive component. This can lead to excessive side effects and/or weight loss. Despite this, long-term weight regain can also occur.

OBJECTIVES

To determine the rate of and options for revision in patients who experience excessive side effects and weight loss. To explore the revisional procedures available to overcome weight regain.

METHODS

A PubMed search was conducted of all reports published between 1979 and August 31, 2014. Series and case reports on revision or reversal after biliopancreatic diversion with duodenal switch (BPD/DS) or without (BPD) were included.

RESULTS

Revision rates for excessive malabsorption ranges from .5%-4.9% and 3%-18.5% after BPD/DS and BPD respectively. Revisions increase common channel by up to 150 cm. Reversal is necessary in .2%-7% of cases, with an increased risk when the common channel is ≤ 50 cm. In most instances, reversal (of the malabsorptive component only) is indicated after the revision failure. A proximal, side-to-side anastomosis between the biliopancreatic and alimentary limbs is the preferred option. Most reoperations are performed within 2 years of the initial procedure and for protein malnutrition in about half of the cases. Revision for insufficient weight loss is reported in .5%-2.78% of cases. Except inadequate channel lengths, little is to be gained by common channel shortening. Additional gastric restriction, which results in an average 9-14 kg weight loss, is another option.

CONCLUSIONS

Biliopancreatic diversion can be relatively easily revised to control excessive side effects and protein malnutrition. Early diagnosis is essential and warrants a close nutritional monitoring. In case of weight regain, limited results can be obtained by reducing the gastric volume provided the lengths of the small bowel channels are adequate.

摘要

背景

胆胰分流术是一种强效的减肥手术,它依靠胃限制与大量的吸收不良成分相结合。这可能导致过多的副作用和/或体重减轻。尽管如此,长期体重反弹也可能发生。

目的

确定出现过多副作用和体重减轻的患者的翻修率及翻修选择。探索可用于克服体重反弹的翻修手术。

方法

对1979年至2014年8月31日期间发表的所有报告进行了PubMed检索。纳入了关于胆胰分流术(伴或不伴十二指肠转位,即BPD/DS或BPD)后翻修或逆转的系列研究和病例报告。

结果

BPD/DS和BPD术后因吸收不良过多而进行翻修的比例分别为0.5%-4.9%和3%-18.5%。翻修可将共同通道增加至150厘米。0.2%-7%的病例需要进行逆转,当共同通道≤50厘米时风险增加。在大多数情况下,翻修失败后需要进行逆转(仅针对吸收不良成分)。胆胰支与消化道支之间近端的侧侧吻合是首选方案。大多数再次手术在初次手术后2年内进行,约一半病例是因蛋白质营养不良。0.5%-2.78%的病例报告因体重减轻不足而进行翻修。除了通道长度不足外,缩短共同通道几乎没有益处。额外的胃限制是另一种选择,平均可减重9-14千克。

结论

胆胰分流术可相对容易地进行翻修以控制过多的副作用和蛋白质营养不良。早期诊断至关重要,需要密切的营养监测。如果出现体重反弹,在小肠通道长度足够的情况下,通过减少胃容量可取得有限的效果。

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