Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan.
Division of Clinical Biostatistics, Research Support Center, Shizuoka General Hospital, Shizuoka, Japan.
Head Neck. 2022 Jun;44(6):1430-1441. doi: 10.1002/hed.27034. Epub 2022 Mar 29.
Salivary duct carcinoma (SDC) is a high-grade salivary malignancy that frequently occurs as the carcinomatous component of carcinoma ex pleomorphic adenoma. We herein examined the clinical factors affecting outcomes in a large cohort of SDC.
We selected 304 SDC cases and investigated clinical characteristics and the factors affecting outcomes.
The median age of the cases examined was 68 years, the most common primary site was the parotid gland (238 cases), and there was a male predominance (M/F = 5:1). Outcomes were significantly worse when the primary tumor site was the minor salivary glands (SG) than when it was the major SG. Outcomes were also significantly worse in pN(+) cases (161 cases) than in pN0 cases, particularly those with a metastatic lymph node number ≥11. The cumulative incidence of relapse and distant metastases was significantly higher in stage IV cases than in stage 0-III cases.
The absolute number of lymph node metastases, higher stages, and the minor SG as the primary tumor site were identified as factors affecting the outcome of SDC.
涎腺导管癌（SDC）是一种高级别涎腺癌，常作为多形性腺瘤癌变的癌性成分出现。本研究旨在探讨影响大样本 SDC 患者预后的临床因素。
我们选择了 304 例 SDC 病例，研究了其临床特征和影响预后的因素。
所研究病例的中位年龄为 68 岁，最常见的原发部位是腮腺（238 例），且以男性为主（M/F=5:1）。与主要涎腺（SG）相比，小涎腺（SG）原发肿瘤患者的预后明显更差。pN(+)病例（161 例）的预后明显差于 pN0 病例，特别是淋巴结转移数≥11 的病例。IV 期病例的复发和远处转移累积发生率明显高于 0-III 期病例。
淋巴结转移的绝对数量、较高的分期和小涎腺作为原发肿瘤部位是影响 SDC 患者预后的因素。
