Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece.
HIV Res Clin Pract. 2022 Dec;23(1):107-119. Epub 2022 Mar 30.
The benefits derived from supervised aerobic exercise in people living with human immunofeficiency virus- HIV (PLWH) have not yet been clearly identified. To evaluate the impact of supervised aerobic exercise on immunological, cardiorespiratory, pulmonary, hemodynamic and mental parameters of PLWH. A systematic review was carried out in accordance to PRISMA guidelines. PubMed, Physiotherapy Evidence Database (PEDro) and Cochrane Central Register of Controlled Trials (CENTRAL) were screened up to August 2021, for the identification of English written randomized trials, with participants aged 18 years and older, at any stage of the disease, with or without co-morbidities. The risk of bias assessment was conducted according to the Cochrane Collaboration's tool for assessing risk of bias. Meta- analyses were conducted using continuous, inverse variance, random-effects model. Ten studies were suitable for meta-analysis based on inclusion criteria. Supervised aerobic exercise appeared to have beneficial effects on depressive symptoms [mean difference (MD)= -4.18 (confidence interval (CI)= (-6.55)-(-1.81), Z = 3.46, = 0.0005, I=0%, n = 2], forced expiratory volume in 1 sec [MD = 0.70, CI = 0.39-1.00, Z = 4.41, < 0.0001, I=0%, n = 2], and on the maximum oxygen uptake [MD = 1.38, CI = -0.02-2.78, Z = 1.94, = 0.05, I=94%, n = 4] of PLWH. No exercise effect was found for CD4 T-cell count ( = 0.16, n = 5), systolic blood pressure ( = 0.91, n = 2) and diastolic blood pressure ( = 0.72, n = 2). Supervised continuous aerobic exercise may improve lung function, depressive symptomatology and aerobic capacity of PLWH, however, the small number of available studies and the high heterogeneity concerning VO2max demonstrate the need for more research in this area.
在人类免疫缺陷病毒（HIV）感染者（PLWH）中，监督下的有氧运动带来的益处尚未明确。本研究旨在评估监督下的有氧运动对 PLWH 的免疫、心肺、肺部、血液动力学和心理参数的影响。按照 PRISMA 指南进行了系统评价。筛选了 PubMed、Physiotherapy Evidence Database（PEDro）和 Cochrane Central Register of Controlled Trials（CENTRAL），以确定截至 2021 年 8 月发表的英语书写的随机试验，参与者年龄在 18 岁及以上，处于疾病的任何阶段，有无合并症。根据 Cochrane 协作组评估偏倚风险的工具对偏倚风险进行了评估。使用连续、逆方差、随机效应模型进行荟萃分析。根据纳入标准，有 10 项研究适合进行荟萃分析。监督下的有氧运动似乎对抑郁症状[平均差异（MD）=-4.18（置信区间（CI）=（-6.55）-（-1.81）），Z=3.46， =0.0005，I=0%，n=2]、1 秒用力呼气量（MD=0.70，CI=0.39-1.00，Z=4.41， <0.0001，I=0%，n=2）和最大摄氧量[MD=1.38，CI=-0.02-2.78，Z=1.94， =0.05，I=94%，n=4]有有益的影响。在 CD4 T 细胞计数（ =0.16，n=5）、收缩压（ =0.91，n=2）和舒张压（ =0.72，n=2）方面没有发现运动效果。监督下的连续有氧运动可能改善 PLWH 的肺功能、抑郁症状和有氧能力，但由于 VO2max 方面可用研究数量较少且存在高度异质性，需要在该领域开展更多研究。
