Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Department of Radiotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022 May;166(2):127-135. doi: 10.5507/bp.2022.016. Epub 2022 Mar 28.
We looked into the most recent studies of digestive tumor patients and performed a meta-analysis to explore the association of CD103+ T cell infiltration with overall survival (OS) in solid tumors of the digestive duct. Major databases were searched. The hazard ratios (HR) and 95% confidence intervals (CI) for overall survival were extracted and pooled. A total of 1915 patients from 11 cohorts were included into the present meta-analysis. The pooled HR was 0.64 (95% CI: 0.42-0.96, P=0.03), suggesting that high CD103+ T cell infiltration is associated with better prognosis. Yet significant heterogeneity was revealed and located in the subgroup of CD4+CD103+ T cells. The pooled result indicated that CD103+ T cell infiltration in solid tumors of the digestive duct may possess predictive value for prognosis. Preclinical studies suggested that CD103+ T cell infiltration could predict response to anti-PD-1/PD-L1 treatment.
我们查阅了最近关于消化道肿瘤患者的研究，并进行了荟萃分析，以探讨 CD103+T 细胞浸润与消化道实体瘤患者总生存（OS）之间的关系。主要数据库进行了检索。提取并汇总了总生存的风险比（HR）和 95%置信区间（CI）。本荟萃分析共纳入了 11 个队列的 1915 名患者。汇总的 HR 为 0.64（95%CI：0.42-0.96，P=0.03），表明 CD103+T 细胞浸润较高与较好的预后相关。然而，存在显著的异质性，且位于 CD4+CD103+T 细胞亚组中。汇总结果表明，CD103+T 细胞浸润可能对消化道实体瘤的预后具有预测价值。临床前研究表明，CD103+T 细胞浸润可预测抗 PD-1/PD-L1 治疗的反应。
