Parghane Rahul V, Basu Sandip
From the Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe; and Homi Bhabha National Institute, Mumbai, India.
Clin Nucl Med. 2022 Oct 1;47(10):874-875. doi: 10.1097/RLU.0000000000004139. Epub 2022 Mar 30.
Thyroid gland and orbit are rare sites of metastases in neuroendocrine tumors. We present an extremely rare case of rectal neuroendocrine tumor with metastases to thyroid gland and intra-orbital regions that demonstrated significant reduction in size and uptake of the lesions on somatostatin receptor based 68 Ga-DOTATATE PET/CT, following 177 Lu-DOTATATE peptide receptor radionuclide therapy. The case illustrates the efficacy of 177 Lu-DOTATATE peptide receptor radionuclide therapy for tumor cytoreduction, which can be considered as a promising treatment modality for somatostatin receptor expressing and tracer-avid metastatic lesions at multiple rare locations.
甲状腺和眼眶是神经内分泌肿瘤转移的罕见部位。我们报告了一例极为罕见的直肠神经内分泌肿瘤转移至甲状腺和眶内区域的病例，该病例在接受177Lu-DOTATATE肽受体放射性核素治疗后，基于生长抑素受体的68Ga-DOTATATE PET/CT显示病变大小和摄取显著减小。该病例说明了177Lu-DOTATATE肽受体放射性核素治疗在肿瘤细胞减灭方面的疗效，对于表达生长抑素受体且对示踪剂摄取阳性的多个罕见部位转移病变而言，可将其视为一种有前景的治疗方式。
